Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels
Abstract
A neuropathologic hallmark of Alzheimer’s disease (AD) is the presence of senile plaques that contain neurotoxic amyloid-β protein (Aβ) species, which are generated by the cleavage of amyloid β-protein precursor by secretases such as the γ-secretase complex, preferentially located in detergent-resistant membrane (DRM) regions and comprising endoproteolysed amino- and carboxy-terminal fragments of presenilin, nicastrin, anterior pharynx defective...
Paper Details
Title
Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels
Published Date
Dec 16, 2019
Journal
Volume
29
Issue
3
Pages
382 - 393
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History