Developments in zebrafish avatars as radiotherapy sensitivity reporters — towards personalized medicine

BackgroundWhereas the role of neoadjuvant radiotherapy in rectal cancer is well-established, the ability to discriminate between radioresistant and radiosensitive tumors before starting treatment is still a crucial unmet need. Here we aimed to develop an in vivo test to directly challenge living cancer cells to radiotherapy, using zebrafish xenografts.MethodsWe generated zebrafish xenografts using colorectal cancer cell lines and patient...