Ensembles of Breathing Nucleosomes: A Computational Study
Abstract
About three-fourths of the human DNA molecules are wrapped into nucleosomes, protein spools with DNA. Nucleosomes are highly dynamic, transiently exposing their DNA through spontaneous unspooling. Recent experiments allowed to observe the DNA of an ensemble of such breathing nucleosomes through x-ray diffraction with contrast matching between the solvent and the protein core. In this study, we calculate such an ensemble through a Monte Carlo...
Paper Details
Title
Ensembles of Breathing Nucleosomes: A Computational Study
Published Date
May 1, 2020
Journal
Volume
118
Issue
9
Pages
2297 - 2308
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