Circulating levels of ATP is a biomarker of HIV cognitive impairment

BackgroundIn developed countries, Human Immunodeficiency Virus type-1 (HIV-1) infection has become a chronic disease despite the positive effects of anti-retroviral therapies (ART), but still at least half of the HIV infected population shown signs of cognitive impairment. Therefore, biomarkers of HIV cognitive decline are urgently needed.MethodsWe analyze the opening of one of the larger channels expressed by humans, pannexin-1 (Panx-1)...