Discovery of Small Molecules for the Reversal of T Cell Exhaustion
Abstract
Inhibitory receptors (IRs) function as critical regulators of immune responses by tempering T cell activity. In humans, several persisting viruses as well as cancers exploit IR signaling by upregulating IR ligands, resulting in suppression of T cell function (i.e., exhaustion). This allows escape from immune surveillance and continuation of disease. Here, we report the design, implementation, and results of a phenotypic high-throughput screen...
Paper Details
Title
Discovery of Small Molecules for the Reversal of T Cell Exhaustion
Published Date
Dec 1, 2019
Journal
Volume
29
Issue
10
Pages
3293 - 3302.e3
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