Two Cocrystals of Berberine Chloride with Myricetin and Dihydromyricetin: Crystal Structures, Characterization, and Antitumor Activities

Two novel drug–drug (1:1) cocrystals of berberine chloride (BER) with myricetin (MYR) and dihydromyricetin (DMY), BER-MYR(1), and BER-DMY(2) have been prepared and investigated systematically. The O–H···Cl– intermolecular interactions formed by hydroxyl groups of MYR and DMY with chloride anion dominated the formation of cocrystals 1 and 2. The values of energy gap (ΔE) and electrophilicity index (ω) computed by density functional theory...