Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens
Abstract
Dysfunction of glutamate neurotransmission in the nucleus accumbens (NAc) has been implicated in the pathophysiology of alcohol use disorders (AUD). Neurogranin (Ng) is exclusively expressed in the brain and mediates N ‐methyl‐ d ‐aspartate receptor (NMDAR) hypo‐function by regulating the intracellular calcium‐calmodulin (Ca 2+ ‐CaM) pathway. Ng null mice (Ng –/– mice) demonstrate increased alcohol drinking compared to wild‐type mice, while also...
Paper Details
Title
Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens
Published Date
Dec 23, 2019
Journal
Volume
20
Issue
1
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