Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride secretion

Yang Li; Mingyuan Tian; Mengliu Yang; Gangyi Yang; Jianrong Chen; Han Wang; Dongfang Liu; Hongyan Wang; Wuquan Deng; Zhiming Zhu; Ling Li

doi:https://doi.org/10.1016/j.metabol.2019.154029

doi.org/10.1016/j.metabol.2019.154029

Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride secretion

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..., Ling Li

30

Metabolism

Volume: 103, Pages: 154029 - 154029

Published: Feb 1, 2020

Abstract

ObjectiveSecreted frizzled-related protein 5 (Sfrp5) has been shown to be associated with energy homeostasis and insulin resistance in mouse models of obesity and diabetes. However, its central role in glucose and lipid metabolism is unknown.MethodsHFD-fed rats received ICV infusions of vehicle or Sfrp5 during a pancreatic euglycemic clamp procedure. To delineate the pathway(s) by which ICV Sfrp5 modulates HGP and VLDL-TG secretion, we inhibited...

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Paper Details

Title

Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride secretion

DOI

doi.org/10.1016/j.metabol.2019.154029

Published Date

Feb 1, 2020

Journal

Metabolism

Volume

103

Pages

154029 - 154029

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