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Metabolism-clinical and Experimental
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#1Marie Rhee (Catholic University of Korea)H-Index: 5
#2Ji-Won Kim (Catholic University of Korea)H-Index: 15
Last.Seung Whan Lee (Catholic University of Korea)H-Index: 62
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Abstract Background Increasing adaptive thermogenesis in adipose tissue may be a potential therapeutic target for overcoming obesity and obesity-related disorders. Preadipocyte factor 1 (Pref-1), a preadipocyte secreted protein, plays an inhibitory role in adipogenic differentiation. However, the role of Pref-1 in adipose tissue browning remains unknown. We investigated whether Pref-1 regulates thermogenic program and beige fat biogenesis. Methods Pref-1 expression levels were examined in inguin...
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#1James P. O'Callaghan (NIOSH: National Institute for Occupational Safety and Health)H-Index: 48
#2Diane B. Miller (NIOSH: National Institute for Occupational Safety and Health)H-Index: 38
Abstract Neuroinflammation is a condition characterized by the elaboration of proinflammatory mediators within the central nervous system. Neuroinflammation has emerged as a dominant theme in contemporary neuroscience due to its association with neurodegenerative disease states such as Alzheimer's disease, Parkinson's disease and Huntington's disease. While neuroinflammation often is associated with damage to the CNS, it also can occur in the absence of neurodegeneration, e.g., in association wi...
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#1Zoe Petraki (UoC: University of Crete)H-Index: 4
#2Stavros Droubogiannis (UoC: University of Crete)
Last.Cleanthe Spanaki (UoC: University of Crete)H-Index: 20
view all 6 authors...
Abstract Glutamate dehydrogenase 1 (GDH1) contributes to glucose-stimulated insulin secretion in murine β-cells, but not to basic insulin release. The implications of these findings for human biology are unclear as humans have two GDH-specific enzymes: hGDH1 (GLUD1-encoded) and hGDH2 (GLUD2-encoded), a novel enzyme that is highly activated by ADP and L-leucine. Here we studied in vivo glucose homeostasis in transgenic (Tg) mice generated by inserting the GLUD2 gene and its putative regulatory el...
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#1Linling Fan (Fudan University)
#2Hongying Ye (Fudan University)H-Index: 9
Last.Yi Wang (Fudan University)H-Index: 11
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Abstract Objectives The activation of brown adipose tissue (BAT) is considered as a promising therapeutic target for obesity. APPL1 (Adaptor protein containing the Pleckstrin homology domain, Phosphotyrosine binding domain and Leucine zipper motif) is an intracellular adaptor protein and its genetic variation is correlated with BMI and body fat distribution in diabetic patients. However, little is known about the roles of APPL1 in BAT thermogenesis. Materials/methods In this study, adipose tissu...
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#1Anouar Hafiane (MUHC: McGill University Health Centre)H-Index: 14
#2Karina Gasbarrino (MUHC: McGill University Health Centre)H-Index: 1
Last.Stella S. Daskalopoulou (MUHC: McGill University Health Centre)H-Index: 38
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Abstract Cholesterol efflux is the initial step in the reverse cholesterol transport pathway by which excess cholesterol in peripheral cells is exported and subsequently packaged into high-density lipoprotein (HDL) particles. Adiponectin is the most abundantly secreted adipokine that possesses anti-inflammatory and vasculoprotective properties via interaction with transmembrane receptors, AdipoR1 and AdipoR2. Evidence suggests that low levels of adiponectin may be a useful marker for atheroscler...
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#1Jizheng Chen (CAS: Chinese Academy of Sciences)H-Index: 7
#2Yue Zhou (Nanjing Medical University)H-Index: 2
Last.Qian Wang (Nanjing Medical University)H-Index: 13
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Abstract Background Chronic hepatitis C virus (HCV) infection can predispose the host to metabolic abnormalities. The orphan nuclear receptor small heterodimer partner (SHP; NR0B2) has been identified as a key transcriptional regulatory factor of genes involved in diverse metabolic pathways. The protective effects of SHP against HCV-induced hepatic fibrosis have been reported. However, the exact mechanisms of its role on metabolism are largely unknown. We investigated the role of hepatic SHP in ...
1 CitationsSource
#1Alexander Kokkinos (UoA: National and Kapodistrian University of Athens)H-Index: 15
#2Dimitrios Tsilingiris (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last.Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
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Abstract Bariatric surgery is currently the most effective therapeutic modality through which sustained beneficial effects on weight loss and metabolic improvement are achieved. During recent years, indications for bariatric surgery have been expanded to include cases of poorly controlled type 2 (T2DM) diabetes mellitus in lesser extremes of body weight. A spectrum of the beneficial effects of surgery is attributed to robust changes of postprandial gut peptide responses that are observed post op...
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#1Johannetremblay (UdeM: Université de Montréal)H-Index: 48
#2Pavel Hamet (UdeM: Université de Montréal)H-Index: 74
Abstract Diabetes mellitus (DM) is a heterogeneous group of disorders characterized by persistent hyperglycemia. Its two most common forms are type 1 diabetes (T1D) and type 2 diabetes (T2D), for which genetic and environmental risk factors act in synergy. Because it occurs in children and involves infectious, autoimmune or toxic destruction of the insulin-secreting pancreatic beta-cells, type 1 diabetes has been called juvenile or insulin-deficient diabetes. In type 2, patients can still secret...
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#1Yang Ching ChenH-Index: 8
#2Hsien-Yu Fan (NTU: National Taiwan University)
Last.Yungling Leo Lee (NTU: National Taiwan University)H-Index: 28
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Abstract Aims Obesity and early puberty have been reported to be mutually causative. We investigated the causal relationship between adiposity and early puberty by performing bidirectional Mendelian randomization (MR) and longitudinal data analyses. Methods We used information from the Taiwan Children Health Study (3109 adolescents aged 11–12 years) with 17 body mass index (BMI)- and 10 puberty-related single-nucleotide polymorphisms (SNPs) to produce genetic instrumental variables (IVs). The tw...
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#1Bridget DiPrisco (Boston Children's Hospital)H-Index: 1
#2Ajay KumarH-Index: 82
Last.Christos S. Mantzoros (Harvard University)H-Index: 106
view all 9 authors...
Abstract Background A newborn's birth weight for gestational age provides important insights into his or her fetal growth and well-being. While the underlying mechanisms regulating fetal growth remain to be fully elucidated, the IGF-axis plays an important role. Some components of this axis have been well-characterized in umbilical cord blood, but others have not yet been studied. We measured the proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and the established...
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Top fields of study
Endocrinology
Insulin
Diabetes mellitus
Medicine
Biology