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Metabolism-clinical and Experimental
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Published on 2019in Metabolism-clinical and Experimental6.51
Zoe Petraki4
Estimated H-index: 4
(UoC: University of Crete),
Stavros Droubogiannis (UoC: University of Crete)+ 3 AuthorsCleanthe Spanaki19
Estimated H-index: 19
(UoC: University of Crete)
Abstract Glutamate dehydrogenase 1 (GDH1) contributes to glucose-stimulated insulin secretion in murine β-cells, but not to basic insulin release. The implications of these findings for human biology are unclear as humans have two GDH-specific enzymes: hGDH1 (GLUD1-encoded) and hGDH2 (GLUD2-encoded), a novel enzyme that is highly activated by ADP and L-leucine. Here we studied in vivo glucose homeostasis in transgenic (Tg) mice generated by inserting the GLUD2 gene and its putative regulatory el...
Published on 2019in Metabolism-clinical and Experimental6.51
Linling Fan (Fudan University), Hongying Ye8
Estimated H-index: 8
(Fudan University)
+ 7 AuthorsQiongyue Zhang6
Estimated H-index: 6
(Fudan University)
Abstract Objectives The activation of brown adipose tissue (BAT) is considered as a promising therapeutic target for obesity. APPL1 (Adaptor protein containing the Pleckstrin homology domain, Phosphotyrosine binding domain and Leucine zipper motif) is an intracellular adaptor protein and its genetic variation is correlated with BMI and body fat distribution in diabetic patients. However, little is known about the roles of APPL1 in BAT thermogenesis. Materials/Methods. In this study, adipose tiss...
Published on 2019in Metabolism-clinical and Experimental6.51
Jizheng Chen6
Estimated H-index: 6
(CAS: Chinese Academy of Sciences),
Yue Zhou1
Estimated H-index: 1
(Nanjing Medical University)
+ 7 AuthorsQian Wang11
Estimated H-index: 11
(Nanjing Medical University)
Abstract Background Chronic hepatitis C virus (HCV) infection can predispose the host to metabolic abnormalities. The orphan nuclear receptor small heterodimer partner (SHP; NR0B2) has been identified as a key transcriptional regulatory factor of genes involved in diverse metabolic pathways. The protective effects of SHP against HCV-induced hepatic fibrosis have been reported. However, the exact mechanisms of its role on metabolism are largely unknown. We investigated the role of hepatic SHP in ...
Published on 2019in Metabolism-clinical and Experimental6.51
Anouar Hafiane13
Estimated H-index: 13
(MUHC: McGill University Health Centre),
Karina Gasbarrino (MUHC: McGill University Health Centre), Stella S. Daskalopoulou38
Estimated H-index: 38
(MUHC: McGill University Health Centre)
Abstract Cholesterol efflux is the initial step in the reverse cholesterol transport pathway by which excess cholesterol in peripheral cells is exported and subsequently packaged into high-density lipoprotein (HDL) particles. Adiponectin is the most abundantly secreted adipokine that possesses anti-inflammatory and vasculoprotective properties via interaction with transmembrane receptors, AdipoR1 and AdipoR2. Evidence suggests that low levels of adiponectin may be a useful marker for atheroscler...
Published on 2019in Metabolism-clinical and Experimental6.51
Alexander Kokkinos14
Estimated H-index: 14
(UoA: National and Kapodistrian University of Athens),
Dimitrios Tsilingiris (UoA: National and Kapodistrian University of Athens)+ 2 AuthorsChristos S. Mantzoros103
Estimated H-index: 103
(BIDMC: Beth Israel Deaconess Medical Center)
Abstract Bariatric surgery is currently the most effective therapeutic modality through which sustained beneficial effects on weight loss and metabolic improvement are achieved. During recent years, indications for bariatric surgery have been expanded to include cases of poorly controlled type 2 (T2DM) diabetes mellitus in lesser extremes of body weight. A spectrum of the beneficial effects of surgery is attributed to robust changes of postprandial gut peptide responses that are observed post op...
Published on 2019in Metabolism-clinical and Experimental6.51
Bridget DiPrisco (Boston Children's Hospital), Arvind Kumar105
Estimated H-index: 105
+ 6 AuthorsChristos S. Mantzoros103
Estimated H-index: 103
(Harvard University)
Abstract Background A newborn's birth weight for gestational age provides important insights into his or her fetal growth and well-being. While the underlying mechanisms regulating fetal growth remain to be fully elucidated, the IGF-axis plays an important role. Some components of this axis have been well-characterized in umbilical cord blood, but others have not yet been studied. We measured the proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and the established...
Published on 2019in Metabolism-clinical and Experimental6.51
Yue Sun (Lanzhou University), Ya Gao (Lanzhou University)+ 6 AuthorsJinhui Tian20
Estimated H-index: 20
(Lanzhou University)
Abstract To systematically review clinical practice guidelines (CPGs) on diabetes foot and assess the consistency of recommendations, quality of CPGs and to present an evidence-map for explicating research trends and gaps. We performed a literature search on PubMed, Embase, and Web of Science, guideline databases and websites of diabetes society to include the diabetic CPGs. The basic information, recommendations for the diabetic foot, methodological quality and reporting quality of diabetic CPG...
Published on Jul 1, 2019in Metabolism-clinical and Experimental6.51
Yunqin Ma1
Estimated H-index: 1
(SJTU: Shanghai Jiao Tong University),
Mingliang Zhang10
Estimated H-index: 10
(SJTU: Shanghai Jiao Tong University)
+ 5 AuthorsWeiping Jia54
Estimated H-index: 54
(SJTU: Shanghai Jiao Tong University)
Abstract Background Perturbed endoplasmic reticulum (ER) homeostasis and increased levels of G0/G1 Switch Gene 2 (G0S2) have been documented in animal models with fatty liver disease. In this study, we investigated whether G0S2 is regulated by branch of the unfolded protein response (UPR) and contributes to ER stress-induced hepatic steatosis. Methods We first analyzed G0S2 expression and the state of the three canonical UPR branches in several hepatic steatosis models, tunicamycin-treated C57BL...
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