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#1Konstantina Georgila (UoC: University of Crete)H-Index: 1
#2Michalis Gounis (UoC: University of Crete)
Last. Aristides G. Eliopoulos (UoA: National and Kapodistrian University of Athens)H-Index: 2
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Abstract Background Apolipoprotein A-I (ApoA-I) is involved in reverse cholesterol transport as a major component of HDL, but also conveys anti-thrombotic, anti-oxidative, anti-inflammatory and immune-regulatory properties that are pertinent to its protective roles in cardiovascular, inflammatory and malignant pathologies. Despite the pleiotropy in ApoA-I functions, the regulation of intracellular ApoA-I levels remains poorly explored. Methods HepG2 hepatoma cells and primary mouse hepatocytes w...
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#1Astrid Johannesson Hjelholt (Aarhus University Hospital)H-Index: 1
#2Esben Søndergaard (Aarhus University Hospital)H-Index: 11
Last. Jens Otto Lunde Jørgensen (Aarhus University Hospital)H-Index: 69
view all 6 authors...
Abstract Objectives Lipoprotein lipase (LPL) catalyzes the hydrolysis of circulating triglycerides into free fatty acids (FFA) and thereby promotes FFA uptake in peripheral tissues. LPL is negatively regulated by angiopoietin-like protein 4 (ANGPTL4) presumably by an FFA-dependent mechanism. Growth hormone (GH) suppresses LPL activity, but it is unknown whether this is mediated by FFA and ANGPTL4. Therefore, we investigated the concerted effect of GH on ANGPTL4 and LPL in the presence and absenc...
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#1So-Young Kwak (KU: Korea University)H-Index: 1
#2InHyeok Chung (KU: Korea University)
Last. Oh Yoen Kim (Dong-a University)H-Index: 29
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Abstract Background Based on the metabolic effect of exogenous ATPase inhibitory factor 1 (IF1) on glucose metabolism, we tested whether IF1 treatment is effective in ameliorating weight gain and whether its effects are sex specific. Methods HFD-fed C57BL/6 mice were treated with IF1 (5 mg/kg body weight, injected intraperitoneally). The underlying mechanisms of effect of IF1 on body weight were investigated in vitro and in vivo. Associations between genotypes of IF1 and obesity and relevant phe...
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#1Alessandro Mengozzi (UniPi: University of Pisa)H-Index: 2
#2Domenico Tricò (UniPi: University of Pisa)H-Index: 9
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Abstract Background/aims Uncertainty still exists on the earliest beta-cell defects at the bases of the type 2 diabetes. We assume that this depends on the inaccurate distinction between fasting and post-load glucose homeostasis and aim at providing a description of major beta-cell functions across the full physiologic spectrum of each condition. Methods In 1320 non-diabetic individuals we performed an OGTT with insulin secretion modeling and a euglycemic insulin clamp, coupled in subgroups to g...
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#1Hyun Sup Kang (Korea Research Institute of Bioscience and Biotechnology)H-Index: 1
#2Jaeho Lee (Korea Research Institute of Bioscience and Biotechnology)H-Index: 1
Last. Sang Chul Lee (Korea Research Institute of Bioscience and Biotechnology)H-Index: 17
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Abstract Objective Brown adipocytes play important roles in the regulation of energy homeostasis by uncoupling protein 1-mediated non-shivering thermogenesis. Recent studies suggest that brown adipocytes as novel therapeutic targets for combating obesity and associated diseases, such as type II diabetes. However, the molecular mechanisms underlying brown adipocyte differentiation and function are not fully understood. Methods We employed previous findings obtained through proteomic studies perfo...
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#1Honglin Sun (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Gang Wei (SJTU: Shanghai Jiao Tong University)
Last. Suzhen Chen (SJTU: Shanghai Jiao Tong University)H-Index: 2
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Abstract Background Hepatic ER stress is a risk factor of insulin resistance and type 2 diabetes. X-box binding protein 1 spliced (XBP1s), a transcription factor, plays a key role in ameliorating insulin resistance and maintaining glucose homeostasis. Unfortunately, the short half-life of the protein dampens its clinical application, and the specific site of lysine residue that could be ubiquitinated and involved in the degradation of XBP1s remains elusive. Methods and Results Here, we identifie...
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#1Xiao Wei (Third Military Medical University)H-Index: 5
#2Xing Wei (Third Military Medical University)H-Index: 6
Last. Gangyi Yang (CQMU: Chongqing Medical University)H-Index: 23
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Abstract The impairment of podocyte protein filtration function caused by excessive mitochondrial calcium intake is a critical feature of diabetic nephropathy (DN). Ca2+ channel transient receptor potential cation channel subfamily V member 1 (TRPV1) has been reported to protect against ischemia-reperfusion induced acute renal injury, but there is no report about its role in DN. Here, we report that dietary capsaicin potently inhibits and reverses chronic renal structural and functional damages ...
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#1Lijie Tian (Tianjin Medical University)H-Index: 2
#2Hongyan Xiao (Tianjin Medical University)
Last. Baoli Wang (Tianjin Medical University)H-Index: 2
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Abstract Background Sprouty (SPRY) proteins play critical roles in controlling cell proliferation, differentiation, and survival by inhibiting receptor tyrosine kinase (RTK)-mediated extracellular signal-regulated kinase (ERK) signaling. Recent studies have demonstrated that SPRY4 negatively regulates angiogenesis and tumor growth. However, whether SPRY4 regulates osteogenic and/or adipogenic differentiation of mesenchymal stem cells remains to be explored. Results In this study, we investigated...
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#1Erdi Sozen (Marmara University)H-Index: 6
#2Burak Yazgan (Marmara University)H-Index: 4
Last. Nesrin Kartal Ozer (Marmara University)H-Index: 23
view all 7 authors...
Abstract Background Cardiovascular diseases (CVDs), with highest mortality and morbidity rates, are the major cause of death in the world. Due to the limited information on heart tissue changes, mediated by hypercholesterolemia, we planned to investigate molecular mechanisms of endoplasmic reticulum (ER) stress and related cell death in high cholesterol fed rabbit model and possible beneficial effects of α-tocopherol. Methods Molecular changes in rabbit heart tissue and cultured cardiomyocytes (...
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#1Jeffrey van Son (UMCG: University Medical Center Groningen)
#2Suzanne P. Stam (UMCG: University Medical Center Groningen)H-Index: 2
Last. Vincent E. de Meijer (UMCG: University Medical Center Groningen)H-Index: 15
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Abstract Background Short-term survival after orthotopic liver transplantation (OLT) has improved over the past decades, but long-term survival remains impaired. The effects of obesity on long-term survival after OLT are controversial. Because pre-transplant body mass index (BMI) can be confounded by ascites, we hypothesized that post-transplant BMI at 1 year could predict long-term survival. Methods A post-hoc analysis was performed of an observational cohort study consisting of adult recipient...
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Top fields of study
Endocrinology
Insulin
Diabetes mellitus
Medicine
Biology