Original paper
Irradiation impairs mitochondrial function and skeletal muscle oxidative capacity: significance for metabolic complications in cancer survivors
Abstract
Metabolic complications are highly prevalent in cancer survivors treated with irradiation but the underlying mechanisms remain unknown.Chow or high fat-fed C57Bl/6J mice were irradiated (6Gy) before investigating the impact on whole-body or skeletal muscle metabolism and profiling their lipidomic signature. Using a transgenic mouse model (Tg:Pax7-nGFP), we isolated muscle progenitor cells (satellite cells) and characterised their metabolic...
Paper Details
Title
Irradiation impairs mitochondrial function and skeletal muscle oxidative capacity: significance for metabolic complications in cancer survivors
Published Date
Feb 1, 2020
Journal
Volume
103
Pages
154025 - 154025
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Notes
History