Intermittent hypoxia activates the Interleukin (IL)-1ß and nuclear factor (NF)?B signaling pathway in primary murine macrophages

Background: Intermittent hypoxia (IH) plays a key role in the pathogenesis of insulin resistance in obstructive sleep apnoea (OSA). We have previously shown that IH induces a pro-inflammatory phenotype in the adipose tissue with M1 macrophage polarization impeding insulin signalling¹. However, the signaling mechanisms remain to be elucidated. Here, we tested the hypothesis that IH activates the IL-1β and NFᵏB/IL-6 pathway in...