Original paper
Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation
Abstract
Traditional CRISPR/Cas9-based gene knockouts are generated by introducing DNA double-strand breaks (DSBs), but this may cause excessive DNA damage or cell death. CRISPR-based cytosine base editors (CBEs) and adenine base editors (ABEs) can facilitate C-to-T or A-to-G exchanges, respectively, without DSBs. CBEs have been employed in a gene knockout strategy: CRISPR-STOP or i-STOP changes single nucleotides to induce in-frame stop codons. However,...
Paper Details
Title
Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation
Published Date
Feb 1, 2020
Journal
Volume
28
Issue
2
Pages
431 - 440
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Notes
History