Improved Outcomes with Cyclophosphamide/Total Body Irradiation 14 Gy Compared to Cyclophosphamide/Total Body Irradiation 12 Gy in Patients with Acute Lymphoblastic Leukemia Undergoing Myeloablative Allogeneic Transplantation

Introduction: Although the most widely-used myeloablative conditioning (MAC) regimen has been a combination of high dose cyclophosphamide (Cy) and total body irradiation (TBI), the optimal radiation dose has not been fully elucidated. While there is evidence that doses exceeding 13 Gy decreases relapse rates, this is associated with excess toxicity. The standard MAC regimen for hematological malignancies at Dana-Farber Cancer Institute prior to...