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Retinal vasculometric characteristics and their associations with polymyalgia rheumatica and giant cell arteritis in a prospective cohort: EPIC-Norfolk Eye Study

Published on Apr 1, 2020in Annals of the Rheumatic Diseases14.299
· DOI :10.1136/ANNRHEUMDIS-2019-216078
Max Yates8
Estimated H-index: 8
,
R.A. Welikala6
Estimated H-index: 6
(KUL: Kingston University)
+ 11 AuthorsPaul J. Foster64
Estimated H-index: 64
(UCL Institute of Ophthalmology)
Abstract
Both polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) have been associated with an increased future risk of cardiovascular disease (CVD).1 However, it remains uncertain whether this is a consequence of inflammatory disease or relates to a common underlying mechanism. Retinal vascular images are a sensitive measures of vascular health, which are emerging as important biomarkers of future cardiovascular risk with changes affecting arterioles and venules.2 In this study, we assess whether vasculometric features associated with CVD are detectable prior to the onset of PMR and GCA. We analysed data from initially healthy subjects enrolled in the EPIC-Norfolk Study, a prospective population-based cohort which enrolled participants between the years 1993 and 1997.3 4 Digital photographs of the retinal fundus were taken of 8112 participants between 2004 and 2011 using a TRC-NW6S non-mydriatic retinal camera and IMAGEnet Telemedicine System (Topcon Corporation, Tokyo, Japan) with a 10 MP Nikon D80 camera (Nikon Corporation, Tokyo, Japan). Retinal vessel widths were measured using the QUARTZ (QUantitative Analysis of Retinal vessel Topology and siZe) programme.5 The fully automated algorithm uses an ensemble classifier of bagged decision trees to allocate vessels into arterioles and venules at 80% probability and calculates summary measures for each participant with an averaged measure between right and left eyes. Cases of PMR …
  • References (6)
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#1Christopher G. Owen (St George's, University of London)H-Index: 45
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Purpose To examine associations between retinal vessel morphometry and cardiometabolic risk factors in older British men and women. Design Retinal imaging examination as part of the European Prospective Investigation into Cancer—Norfolk Eye Study. Participants Retinal imaging and clinical assessments were carried out in 7411 participants. Retinal images were analyzed using a fully automated validated computerized system that provides novel measures of vessel morphometry. Methods Associations bet...
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Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, are associated with an increased risk of coronary artery disease (CAD) as a result of accelerated atherosclerosis. However, the data on CAD risk of polymyalgia rheumatica (PMR), one of the most common chronic inflammatory disorders in older adults, remain unclear due to limited number of epidemiological studies. To further investigate this possible association, this systematic review and meta-a...
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#1R.A. Welikala (KUL: Kingston University)H-Index: 6
#2Muhammad Moazam Fraz (National University of Sciences and Technology)H-Index: 14
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Morphological changes in the retinal vascular network are associated with future risk of many systemic and vascular diseases. However, uncertainty over the presence and nature of some of these associations exists. Analysis of data from large population based studies will help to resolve these uncertainties. The QUARTZ (QUantitative Analysis of Retinal vessel Topology and siZe) retinal image analysis system allows automated processing of large numbers of retinal images. However, an image quality ...
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Objectives: To summarise the methods of the European Prospective Investigation of Cancer (EPIC)Norfolk Eye Study, and to present data on the prevalence of visual impairment and associations with visual impairment in the participants. Design: A population-based cross-sectional study nested within an on-going prospective cohort study (EPIC). Setting: East England population (the city of Norwich and its surrounding small towns and rural areas). Participants: A total of 8623 participants aged 48–92 ...
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