GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis
Abstract
Although human genetic studies have implicated many susceptible genes associated with plasma lipid levels, their physiological and molecular functions are not fully characterized. Here we demonstrate that orphan G protein-coupled receptor 146 (GPR146) promotes activity of hepatic sterol regulatory element binding protein 2 (SREBP2) through activation of the extracellular signal-regulated kinase (ERK) signaling pathway, thereby regulating hepatic...
Paper Details
Title
GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis
Published Date
Nov 1, 2019
Journal
Volume
179
Issue
6
Pages
1276 - 1288.e14
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