Review paper
The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling
Abstract
Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1-4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly reactive aldehydes, which spontaneously react with surrounding amino groups and other aldehydes to form inter- and intra-catenary...
Paper Details
Title
The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling
Published Date
Nov 21, 2019
Journal
Volume
8
Issue
12
Pages
1483 - 1483
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History