Original paper
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms
Abstract
Histiocytoses are clonal hematopoietic disorders frequently driven by mutations mapping to the BRAF and MEK1 and MEK2 kinases. Currently, however, the developmental origins of histiocytoses in patients are not well understood, and clinically meaningful therapeutic targets outside of BRAF and MEK are undefined. In this study, we uncovered activating mutations in CSF1R and rearrangements in RET and ALK that conferred dramatic responses to...
Paper Details
Title
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms
Published Date
Nov 25, 2019
Journal
Volume
25
Issue
12
Pages
1839 - 1842
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Notes
History