Review paper
Assessment of computational methods for the analysis of single-cell ATAC-seq data
Abstract
Recent innovations in single-cell Assay for Transposase Accessible Chromatin using sequencing (scATAC-seq) enable profiling of the epigenetic landscape of thousands of individual cells. scATAC-seq data analysis presents unique methodological challenges. scATAC-seq experiments sample DNA, which, due to low copy numbers (diploid in humans), lead to inherent data sparsity (1-10% of peaks detected per cell) compared to transcriptomic (scRNA-seq)...
Paper Details
Title
Assessment of computational methods for the analysis of single-cell ATAC-seq data
Published Date
Nov 18, 2019
Journal
Volume
20
Issue
1
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