Original paper

CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart

Volume: 126, Issue: 1, Pages: 6 - 24
Published: Jan 3, 2020
Abstract
Rationale: Genome editing by CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 is evolving rapidly. Recently, second-generation CRISPR/Cas9 activation systems based on nuclease inactive dead (d)Cas9 fused to transcriptional transactivation domains were developed for directing specific guide (g)RNAs to regulatory regions of any gene of interest, to enhance transcription. The application of dCas9 to activate cardiomyocyte...
Paper Details
Title
CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart
Published Date
Jan 3, 2020
Volume
126
Issue
1
Pages
6 - 24
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