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Circulation Research
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#1Yuan Zhang (Guangzhou Medical University)H-Index: 3
Last. Xuejiao Fan (Guangzhou Medical University)H-Index: 1
view all 16 authors...
Rationale: Kawasaki disease (KD) is an acute vasculitis of early childhood that can result in per-manent coronary artery structural damage. The etiology for this arterial vulnerability in up to 15% of KD patients is unknown. Vascular smooth muscle cell (VSMC) dedifferentiation play a key role in the pathophysiology of medial damage and aneurysm formation, recognized arterial pathology in KD. Platelet hyperreactivity is also a hallmark of KD. We recently demonstrated that uptake of platelets and ...
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#1James D. McFadyenH-Index: 11
#2Hannah C. StevensH-Index: 6
Last. Karlheinz PeterH-Index: 52
view all 3 authors...
The recent emergence of SARS-CoV-2 and the ensuing global pandemic has presented a health emergency of unprecedented magnitude. Recent clinical data has highlighted that COVID-19 is associated with a significant risk of thrombotic complications ranging from microvascular thrombosis, venous thromboembolic disease and stroke. Importantly, thrombotic complications are markers of severe COVID-19 and are associated with multi-organ failure and increased mortality. The evidence to date supports the co...
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#1Miao Feng (French Institute of Health and Medical Research)
#2Ziane Elaib (French Institute of Health and Medical Research)H-Index: 3
Last. Regis Bobe (French Institute of Health and Medical Research)H-Index: 22
view all 8 authors...
Rationale: Ca2+ signaling is a key and ubiquitous actor of cell organization and its modulation controls many cellular responses. Sarco-endoplasmic reticulum Ca2+-ATPases (SERCAs) pump Ca2+ into internal stores that play a major role in the cytosolic Ca2+ concentration rise upon cell activation. Platelets exhibit 2 types of SERCAs, SERCA2b and SERCA3, which may exert specific roles, yet ill-defined. We have recently shown that Ca2+ mobilization from SERCA3-dependent stores was required for full ...
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#1Jedrzej Hoffmann (Goethe University Frankfurt)H-Index: 15
Last. Andreas M. Zeiher (Goethe University Frankfurt)H-Index: 137
view all 9 authors...
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#1Michelle C. FlynnH-Index: 4
#2Michael J Kraakman (Columbia University)H-Index: 12
Last. Tessa J. Barrett (NYU: New York University)H-Index: 11
view all 26 authors...
Rationale: Treatment efficacy for diabetes is largely determined by assessment of HbA1c levels, which poorly reflects direct glucose variation. People with pre-diabetes and diabetes spend >50% of their time outside the optimal glucose range. These glucose variations, termed transient intermittent hyperglycemia (TIH) appear to be an independent risk-factor for cardiovascular disease (CVD) but the pathological basis for this association is unclear. Objective: To determine whether TIH per se promot...
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#1Konstantinos C. Siontis (Mayo Clinic)H-Index: 19
#2Xiaoxi Yao (Mayo Clinic)H-Index: 16
Last. Peter A. Noseworthy (Mayo Clinic)H-Index: 34
view all 5 authors...
2 CitationsSource
#1Yen-Sin Ang (Amgen)H-Index: 1
#2Sridharan Rajamani (Amgen)H-Index: 27
Last. Jörg Hüser (Bayer)H-Index: 2
view all 4 authors...
2 CitationsSource
#1Eric Y. Ding (UMMS: University of Massachusetts Medical School)H-Index: 5
#2Gregory M. Marcus (UCSF: University of California, San Francisco)H-Index: 43
Last. David D. McManus (UMMS: University of Massachusetts Medical School)H-Index: 43
view all 3 authors...
1 CitationsSource
#1M. Benjamin Shoemaker (VUMC: Vanderbilt University Medical Center)H-Index: 16
#2Rajan L. Shah (Stanford University)H-Index: 1
Last. Marco V. Perez (Stanford University)H-Index: 27
view all 4 authors...
Susceptibility to atrial fibrillation (AF) is determined by well-recognized risk factors such as diabetes mellitus or hypertension, emerging risk factors such as sleep apnea or inflammation, and in...
2 CitationsSource
#1Shaan Khurshid (MIT: Massachusetts Institute of Technology)H-Index: 9
#2Jeff S. Healey (Population Health Research Institute)H-Index: 65
Last. Steven A. Lubitz (MIT: Massachusetts Institute of Technology)H-Index: 49
view all 4 authors...
Atrial fibrillation (AF) is a common and morbid arrhythmia. Stroke is a major hazard of AF and may be preventable with oral anticoagulation. Yet since AF is often asymptomatic, many individuals wit...
1 CitationsSource
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Top fields of study
Endocrinology
Cardiology
Diabetes mellitus
Biology
Cell biology