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Risk Factors for Alanine Aminotransferase Elevations in a Prospective Cohort of HIV-Infected Tanzanian Adults Initiating Antiretroviral Therapy

Published on Oct 31, 2019in Journal of the International Association of Providers of AIDS Care
· DOI :10.1177/2325958219884939
Sabina Mugusi11
Estimated H-index: 11
(Harvard University),
David Sando11
Estimated H-index: 11
(Harvard University)
+ 4 AuthorsChristopher R. Sudfeld21
Estimated H-index: 21
(Harvard University)
Abstract
Introduction:Serum alanine aminotransferase (ALT) elevations are common among HIV-infected patients on combination antiretroviral therapy (cART).Approach:We conducted a prospective cohort study of ...
  • References (32)
  • Citations (0)
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References32
Newest
#2Ashley L BuchananH-Index: 11
Last. Wafaie W. FawziH-Index: 65
view all 11 authors...
Source
#1P.A. Mataranyika (UNAM: University of Namibia)H-Index: 1
#2Dan Kibuule (UNAM: University of Namibia)H-Index: 10
Last. Timothy Rennie (UNAM: University of Namibia)H-Index: 6
view all 6 authors...
Introduction: All antiretroviral therapies (ARTs) are potentially toxic to the liver. In sub-Saharan Africa, the rising incidence of ART induced adverse events has complicated treatment leading to recent revisions of Namibian ART guidelines. Unfortunately there have been limited studies to date evaluating ART induced liver injury in Namibia to guide further revisions if needed. Objective: Determine the current patterns and grades of ALT elevation in Namibia’s HIV/AIDS. Methods: Retrospective coh...
6 CitationsSource
#1Matthew B Kaspar (MCV: VCU Medical Center)H-Index: 1
#2Richard K. SterlingH-Index: 58
Objective To describe the various mechanisms of liver disease in patients with HIV infection, and to link these mechanisms to disease states which may utilise them. Background Non-AIDS causes of morbidity and mortality are becoming increasingly common in patients chronically infected with HIV. In particular, liver-related diseases have risen to become one of the leading causes of non-AIDS-related death. A thorough understanding of the mechanisms driving the development of liver disease in these ...
12 CitationsSource
#1Maren C. Podszun (University of Hohenheim)H-Index: 4
#2Jan Frank (University of Hohenheim)H-Index: 29
Abstract Vitamin E (α-, β-, γ- and δ-tocopherol and -tocotrienol) is an essential factor in the human diet and regularly taken as a dietary supplement by many people, who act under the assumption that it may be good for their health and can do no harm. With the publication of meta-analyses reporting increased mortality in persons taking vitamin E supplements, the safety of the micronutrient was questioned and interactions with prescription drugs were suggested as one potentially underlying mecha...
9 CitationsSource
#1Sheila Isanaka (Harvard University)H-Index: 14
#2Ferdinand Mugusi (MUHAS: Muhimbili University of Health and Allied Sciences)H-Index: 30
Last. Wafaie W. Fawzi (Harvard University)H-Index: 65
view all 8 authors...
Context Large randomized trials have previously shown that high-dose micronutrient supplementation can increase CD4 counts and reduce human immunodeficiency virus (HIV) disease progression and mortality among individuals not receiving highly active antiretroviral therapy (HAART); however, the safety and efficacy of such supplementation has not been established in the context of HAART. Objective To test the hypothesis that high-dose multivitamin supplementation vs standard-dose multivitamin suppl...
39 CitationsSource
24 CitationsSource
#1Tumaini J. Nagu (MUHAS: Muhimbili University of Health and Allied Sciences)H-Index: 6
Last. Wafaie W. Fawzi (Harvard University)H-Index: 65
view all 8 authors...
Alanine aminotransferase (ALT) is commonly used to measure liver injury in resource-limited settings. Elevations in ALT are predictive of increased mortality from liver disease and may influence the choice of first-line antiretroviral therapy (ART). A cross-sectional analysis of the prevalence and predictors of elevated ALT (defined as >40 IU/L) was conducted. ART-naive, HIV-infected adults with a baseline ALT measurement who were enrolled in any of the 18 HIV Care and Treatment Clinics in Dar e...
6 CitationsSource
#1Bianca M. Arendt (UHN: University Health Network)H-Index: 15
#2Johane P. Allard (UHN: University Health Network)H-Index: 36
Editorial: Effect of Atorvastatin, Vitamin E and C on Nonalcoholic Fatty Liver Disease: Is the Combination Required?
26 CitationsSource
#1Helen Kovari (UZH: University of Zurich)H-Index: 16
#2B. Ledergeber (UZH: University of Zurich)H-Index: 69
Last. Rainer Weber (UZH: University of Zurich)H-Index: 77
view all 10 authors...
BACKGROUND: Chronic liver disease in human immunodeficiency virus (HIV)-infected patients is mostly caused by hepatitis virus co-infection. Other reasons for chronic alanine aminotransferase (ALT) elevation are more difficult to diagnose. METHODS: We studied the incidence of and risk factors for chronic elevation of ALT levels (greater than the upper limit of normal at 2 consecutive semi-annual visits) in participants of the Swiss HIV Cohort Study without hepatitis B virus (HBV) or hepatitis C v...
70 CitationsSource
#1Nancy F. Crum-Cianflone (SDSU: San Diego State University)H-Index: 35
#2Angelica Dilay (SDSU: San Diego State University)H-Index: 1
Last. Charles Hames (NMCSD: Naval Medical Center San Diego)H-Index: 2
view all 13 authors...
Objective To describe the prevalence and factors associated with nonalcoholic fatty liver disease (NAFLD) among HIV-infected persons not infected with hepatitis C virus (HCV).
123 CitationsSource
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