Immunoregulatory Functions of Nuclear Receptors: Mechanisms and Therapeutic Implications

Nuclear receptor superfamily encompasses 48 members in human and its family members have been widely implicated in diseases. The active involvement of nuclear receptors in the regulation of immunity underscores the importance of their immunoregulatory roles in these diseases. As nuclear receptors are potentially actionable and druggable, the nuclear receptor-dependent alterations in the immune system are amenable to pharmacological treatment and...