Original paper
Senescent HUVECs-secreted exosomes trigger endothelial barrier dysfunction in young endothelial cells.
Abstract
Accumulation of senescent endothelial cells can cause endothelium dysfunction which eventually leads to age-related vascular disorders. The senescent-associated secretory phenotype (SASP) cells secrete a plethora of soluble factors that negatively influence the surrounding tissue microenvironment. The present study sought to investigate the effects of exosomes, which are nano-sized extracellular vesicles known for intercellular communications...
Paper Details
Title
Senescent HUVECs-secreted exosomes trigger endothelial barrier dysfunction in young endothelial cells.
Published Date
Jan 1, 2019
Journal
Volume
18
Pages
764 - 776
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Notes
History