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Mohd Rais Mustafa
University of Malaya
EndocrinologyChemistryNitric oxideBiochemistryBiology
146Publications
27H-index
2,656Citations
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Publications 143
Newest
#1Beng Fye Lau (UM: University of Malaya)H-Index: 9
#2Kin Weng Kong (UM: University of Malaya)H-Index: 14
Last. Amin Ismail (UPM: Universiti Putra Malaysia)H-Index: 34
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Abstract Background There is a renewed interest in the utilisation of agricultural by-products, particularly those from crop plants, as a source of functional ingredients. The banana (Musa spp.) is a popular food crop worldwide but its inflorescence is often undervalued, similar to other agricultural by-products. As the banana inflorescence is traditionally consumed as food and medicine, it has the potential to be developed into functional foods. Scope and approach The present review systematica...
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Increased oxidative stress by hyperglycemia is a major cause of vascular complications in diabetes. Bird's nest, which is made from the saliva of swiftlets has both medicinal and nutritional values dated back to ancient China. However, it’s role in improving endothelial dysfunction due to diabetes is yet to be elucidated. The present study examined the protective effect and mechanism of action of the aqueous extract of hydrolyzed edible bird nest (HBN) on endothelium in models of diabetes, in vi...
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#1Wei Chih Ling (UTAR: Universiti Tunku Abdul Rahman)
#1Wei Chih LingH-Index: 6
Last. Dharmani Devi MuruganH-Index: 11
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Nitrite, an anion produced from the oxidative breakdown of nitric oxide (NO), has traditionally been viewed as an inert molecule. However, this dogma has been challenged with the findings that nitrite can be readily reduced to NO under pathological conditions, hence representing a physiologically relevant storage reservoir of NO either in the blood or tissues. Nitrite administration has been demonstrated to improve myocardial function in subjects with heart failure and to lower the blood pressur...
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#1M. Dharmani (UM: University of Malaya)
#2K. Kamarulzaman (Management and Science University)
Last. Mohd Rais Mustafa (UM: University of Malaya)H-Index: 27
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Abstract Background Oestrogen deficiency leads to metabolic disturbances such as insulin resistance and impairment of adipose tissue or lipid metabolism. Marantodes pumilum (Blume) Kuntze (Primulaceae) is believed to have phytoestrogenic properties and is claimed to have beneficial effects in the treatment of diabetes mellitus (DM), but the mechanism behind its phytoestrogenic effects on estrogen-deficient diabetic condition have not been fully examined. Purpose The present study investigated th...
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#1Ker Woon ChoyH-Index: 4
#1Ker Woon Choy (University of Kuala Lumpur)
Last. rais Mustafa (UM: University of Malaya)H-Index: 1
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Cardiovascular diseases (CVDs) such as angina, hypertension, myocardial ischaemia and heart failure are the leading causes of morbidity and mortality worldwide. One of the major transcription factors widely associated with CVDs is nuclear factor-kappa B (NFκB). NFκB activation initiate the canonical and non-conical pathways that promotes activation of transcription factors leading to inflammation, such as leukocyte adhesion molecules, cytokines, and chemokines. Flavonoids are bioactive polypheno...
2 CitationsSource
#1Pooi-Fong WongH-Index: 16
#2Kind-Leng TongH-Index: 1
Last. Mohd Rais MustafaH-Index: 27
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Accumulation of senescent endothelial cells can cause endothelium dysfunction which eventually leads to age-related vascular disorders. The senescent-associated secretory phenotype (SASP) cells secrete a plethora of soluble factors that negatively influence the surrounding tissue microenvironment. The present study sought to investigate the effects of exosomes, which are nano-sized extracellular vesicles known for intercellular communications secreted by SASP cells on young endothelial cells. Ex...
1 CitationsSource
#1See Ziau Hoe (UM: University of Malaya)H-Index: 7
#2Chitra Devi Ramachandran (UM: University of Malaya)
Last. Mohd Rais Mustafa (UM: University of Malaya)H-Index: 27
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Abstract An increase in blood pressure (BP) by a high-salt (HS) diet may involve the changes in the expression of epithelium sodium channels (ENaCs) and aquaporins (AQPs) in the kidney which affect the sodium- and water-handling mechanisms. In the present study, spontaneously hypertensive rats (SHRs) and Wistar Kyoto (WKY) rats were exposed to HS and regular-salt (RS) diets for 6 weeks and fluid intake was monitored. After 6 weeks, mean arterial pressure (MAP) and plasma hormonal activity of atr...
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#1Mohadeseh Hasanpourghadi (UM: University of Malaya)H-Index: 7
#2Nazia Abdul Majid (UM: University of Malaya)H-Index: 15
Last. Mohd Rais Mustafa (UM: University of Malaya)H-Index: 27
view all 3 authors...
Combination Index (CI) analysis suggested that MBIC and doxorubicin synergistically inhibited up to 97% of cell proliferation in ER+/PR+ MCF-7 and triple negative MDA-MB-231 breast cancer cell lines. Moreover, treatment of the breast cancer cells with the combined drugs resulted in lower IC50 values in contrast to the individual drug treatment. Small noncoding microRNAs (miRNA) may function as non-mutational gene regulators at post-transcriptional level of protein synthesis. In the present study...
1 CitationsSource
#1Mohadeseh Hasanpourghadi (UM: University of Malaya)H-Index: 7
#2Nazia Abdul Majid (UM: University of Malaya)H-Index: 15
Last. Mohd Rais Mustafa (UM: University of Malaya)H-Index: 27
view all 3 authors...
Abstract We recently reported that methyl 2-(-5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) is a microtubule targeting agent (MTA) with multiple mechanisms of action including apoptosis in two human breast cancer cell-lines MCF-7 and MDA-MB-231. In the present study, investigation of early molecular events following MBIC treatment demonstrated the induction of autophagy. This early (
2 CitationsSource
#1Ker Woon Choy (UM: University of Malaya)H-Index: 4
#2Dharmani Devi Murugan (UM: University of Malaya)H-Index: 11
Last. Mohd Rais Mustafa (UM: University of Malaya)H-Index: 27
view all 3 authors...
Abstract Endoplasmic reticulum (ER) is the main organelle for the synthesis, folding, and processing of secretory and transmembrane proteins. Pathological stimuli including hypoxia, ischaemia, inflammation and oxidative stress interrupt the homeostatic function of ER, leading to accumulation of unfolded proteins, a condition referred to as ER stress. ER stress triggers a complex signalling network referred as the unfolded protein response (UPR). Extensive studies have demonstrated that ER stress...
10 CitationsSource
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