Combined gene essentiality scoring improves the prediction of cancer dependency maps
Abstract
BackgroundProbing genetic dependencies of cancer cells can improve our understanding of tumour development and progression, as well as identify potential drug targets. CRISPR-Cas9-based and shRNA-based genetic screening are commonly utilized to identify essential genes that affect cancer growth. However, systematic methods leveraging these genetic screening techniques to derive consensus cancer dependency maps for individual cancer cell lines...
Paper Details
Title
Combined gene essentiality scoring improves the prediction of cancer dependency maps
Published Date
Dec 1, 2019
Journal
Volume
50
Pages
67 - 80
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Notes
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