KYNURENINE, AN ENDOGENOUS AHR AGONIST, UPREGULATES CXCL12- AND HDAC3-TARGETING MIRNAS INHIBITING OSTEOGENESIS

Osteoporosis is among the most debilitating disorders for aging men and women. Mechanisms underlying loss of bone mass and impaired fracture healing in aged population are not completely understood. Our lab and others reported increased levels of the oxidized tryptophan metabolite, kynurenine (Kyn), in bone marrow mesenchymal stem cells (BMSCs) and interstitial fluid. Here, we report that Kyn significantly inhibits osteogenic differentiation of...