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Ahmed M. Elmansi
Medical University of South Carolina
5Publications
1H-index
2Citations
Publications 9
Newest
Abstract Osteoporosis is an age-related deterioration in bone health that is, at least in part, a stem cell disease. The different mechanisms and signaling pathways that change with age and contribute to the development of osteoporosis are being identified. One key upstream mechanism that appears to target a number of osteogenic pathways with age is kynurenine, a tryptophan metabolite and an endogenous Aryl hydrocarbon receptor (AhR) agonist. The AhR signaling pathway has been reported to promot...
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Abstract Musculoskeletal disorders are the leading cause of disability worldwide; two of the most prevalent of which are osteoporosis and sarcopenia. Each affect millions in the aging population across the world and the associated morbidity and mortality contributes to billions of dollars in annual healthcare cost. Thus, it is important to better understand the underlying pathologic mechanisms of the disease process. Regulatory chemokine, CXCL12, and its receptor, CXCR4, are recognized to be ess...
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#1Ahmed M. Elmansi (MUSC: Medical University of South Carolina)H-Index: 1
#2Mohamed E. AwadH-Index: 4
Last.William D. HillH-Index: 1
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Abstract Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form. It is responsible for proteolytic cleavage of many peptide substrates. In this review we discuss the idea that DPP4-cleaved peptides are not necessarily inactivated, but rather can possess either a modified receptor selectivity, modifi...
2 CitationsSource
With age, joints become subject to chronic inflammatory processes that lead to degeneration of articular cartilage. Although multifactorial, cytokines have been shown to play a role in the pathogen...
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#1Ahmed M. ElmansiH-Index: 1
#2Khaled A. HusseinH-Index: 8
Last.W Hill
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#1Khaled A. HusseinH-Index: 8
#2Ahmed M. ElmansiH-Index: 1
Last.W Hill
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