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Ahmed M. Elmansi
Medical University of South Carolina
microRNAMesenchymal stem cellAutophagyKynurenineBiology
11Publications
2H-index
12Citations
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Publications 10
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#1Ahmed M. Elmansi (MUSC: Medical University of South Carolina)H-Index: 2
#2Khaled A. HusseinH-Index: 9
Last. Helen Kaiser (Georgia Regents University)H-Index: 3
view all 27 authors...
Abstract Mechanisms leading to age-related reductions in bone formation and subsequent osteoporosis are still incompletely understood. We recently demonstrated that kynurenine (KYN), a tryptophan metabolite, accumulates in serum of aged mice and induces bone loss. Here, we report on novel mechanisms underlying KYN's detrimental effect on bone aging. We show that KYN is increased with aging in murine bone marrow mesenchymal stem cells (BMSCs). KYN reduces bone formation via modulating levels of C...
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#1Dmitry Kondrikov (MUSC: Medical University of South Carolina)H-Index: 2
#2Ahmed M. Elmansi (MUSC: Medical University of South Carolina)H-Index: 2
Last. William D. Hill (MUSC: Medical University of South Carolina)H-Index: 2
view all 15 authors...
Abstract Osteoporosis is an age-related deterioration in bone health that is, at least in part, a stem cell disease. The different mechanisms and signaling pathways that change with age and contribute to the development of osteoporosis are being identified. One key upstream mechanism that appears to target a number of osteogenic pathways with age is kynurenine, a tryptophan metabolite and an endogenous Aryl hydrocarbon receptor (AhR) agonist. The AhR signaling pathway has been reported to promot...
5 CitationsSource
#1Dmitry Kondrikov (MUSC: Medical University of South Carolina)H-Index: 2
#2Ahmed M. Elmansi (MUSC: Medical University of South Carolina)H-Index: 2
Last. William D. Hill (MUSC: Medical University of South Carolina)H-Index: 2
view all 8 authors...
Source
#1Ahmed M. Elmansi (MUSC: Medical University of South Carolina)H-Index: 2
#2Nada Eisa (MUSC: Medical University of South Carolina)H-Index: 1
Last. William D. Hill (MUSC: Medical University of South Carolina)H-Index: 2
view all 8 authors...
Source
#1Dmitry Kondrikov (MUSC: Medical University of South Carolina)H-Index: 2
#2Ahmed M. Elmansi (MUSC: Medical University of South Carolina)H-Index: 2
Last. William D. Hill (MUSC: Medical University of South Carolina)H-Index: 2
view all 8 authors...
Source
#1William GilbertH-Index: 1
#2Robert T. BraggH-Index: 2
Last. Sadanand FulzeleH-Index: 21
view all 8 authors...
Abstract Musculoskeletal disorders are the leading cause of disability worldwide; two of the most prevalent of which are osteoporosis and sarcopenia. Each affect millions in the aging population across the world and the associated morbidity and mortality contributes to billions of dollars in annual healthcare cost. Thus, it is important to better understand the underlying pathologic mechanisms of the disease process. Regulatory chemokine, CXCL12, and its receptor, CXCR4, are recognized to be ess...
2 CitationsSource
With age, joints become subject to chronic inflammatory processes that lead to degeneration of articular cartilage. Although multifactorial, cytokines have been shown to play a role in the pathogen...
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#1Ahmed M. Elmansi (MUSC: Medical University of South Carolina)H-Index: 2
#2Mohamed E. AwadH-Index: 4
Last. William D. HillH-Index: 2
view all 14 authors...
Abstract Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form. It is responsible for proteolytic cleavage of many peptide substrates. In this review we discuss the idea that DPP4-cleaved peptides are not necessarily inactivated, but rather can possess either a modified receptor selectivity, modifi...
5 CitationsSource
#1Khaled A. HusseinH-Index: 9
#2Ahmed M. ElmansiH-Index: 2
Last. W Hill
view all 8 authors...
Source
#1Ahmed M. ElmansiH-Index: 2
#2Khaled A. HusseinH-Index: 9
Last. W Hill
view all 8 authors...
Source
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