Mast cells can be commandeered for staphylococcal pathogenicity in patients with chronic rhinosinusitis with nasal polyposis

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a prevalent condition and a substantial cause of morbidity. It frequently recurs after surgical resection and can be refractory to local and systemic glucocorticoid therapy. In Western countries CRSwNP is most typically associated with eosinophilic inflammation accompanied by epithelial hyperplasia and infiltration and activation of mast cells (MCs). Several factors, including functional...