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Joshua A. Boyce
Brigham and Women's Hospital
ImmunologyInflammationMast cellMedicineBiology
213Publications
50H-index
8,052Citations
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Publications 216
Newest
#1Carly G.K. Ziegler (Ragon Institute of MGH, MIT and Harvard)H-Index: 1
#2Samuel J. Allon (MIT: Massachusetts Institute of Technology)
Last. Blake Hauser (Harvard University)
view all 65 authors...
There is pressing urgency to better understand the pathogenesis of the severe acute respiratory syndrome (SARS) coronavirus (CoV) clade SARS-CoV-2. SARS-CoV-2, like SARS-CoV, utilizes ACE2 to bind host cells. While initial SARS-CoV-2 cell entry and infection depend on ACE2 in concert with the protease TMPRSS2 for spike (S) protein activation, the specific cell subsets targeted by SARS-CoV-2 in host tissues, and the factors that regulate ACE2 expression, remain unknown. Here, we leverage human an...
8 CitationsSource
#1Kathleen M. Buchheit (Brigham and Women's Hospital)H-Index: 6
#2Daniel F. Dwyer (Brigham and Women's Hospital)H-Index: 9
Last. Alex K. ShalekH-Index: 33
view all 13 authors...
Abstract Background The cause of severe nasal polyposis in aspirin-exacerbated respiratory disease (AERD) is unknown. Elevated antibody levels have been associated with disease severity in nasal polyps (NPs), but upstream drivers of local antibody production in NPs are undetermined. Objective We sought to identify upstream drivers and phenotypic properties of local antibody-expressing cells (AECs) in NPs from AERD subjects. Methods Sinus tissue was obtained from subjects with AERD, chronic rhino...
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#1Carly G K Ziegler (Ragon Institute of MGH, MIT and Harvard)H-Index: 2
#2Samuel J. Allon (MIT: Massachusetts Institute of Technology)
Last. Jared E. Feldman (Ragon Institute of MGH, MIT and Harvard)H-Index: 1
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There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) which causes the disease COVID-19. SARS-CoV2 spike (S)-protein binds ACE2, and in concert with host proteases, principally TMPRSS2, promotes cellular entry. The cell subsets targeted by SARS-CoV-2 in host tissues, and the factors that regulate ACE2 expression, remain unknown. Here, we leverage human, non-human primate, and mouse single-cell RNA-sequencing (scRNA-seq)...
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Antagonists of the type 1 cysteinyl leukotriene receptor (CysLT1R) are widely used to treat asthma and allergic rhinitis, with variable response rates. Alveolar macrophages express UDP-specific P2Y6 receptors that can be blocked by off-target effects of CysLT1R antagonists. Sensitizing intranasal doses of an extract from the house dust mite Dermatophagoides farinae (Df) sharply increased the levels of UDP detected in bronchoalveolar lavage fluid of mice. Conditional deletion of P2Y6 receptors be...
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#1Joshua A. Boyce (Brigham and Women's Hospital)H-Index: 50
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