Original paper
Patient-derived organoids as a potential model to predict response to PD-1/PD-L1 checkpoint inhibitors
Abstract
Selection of cancer patients for treatment with immune checkpoint inhibitors remains a challenge due to tumour heterogeneity and variable biomarker detection. PD-L1 expression in 24 surgical chordoma specimen was determined immunohistochemically with antibodies 28-8 and E1L3N. The ability of patient-derived organoids to detect treatment effects of nivolumab was explored by quantitative and qualitative immunofluorescence and FACS analysis. The...
Paper Details
Title
Patient-derived organoids as a potential model to predict response to PD-1/PD-L1 checkpoint inhibitors
Published Date
Oct 31, 2019
Journal
Volume
121
Issue
11
Pages
979 - 982
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Notes
History