British Journal of Cancer
Papers 24809
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#1Bogdan-Alexandru Luca (UEA: University of East Anglia)H-Index: 2
Last. Colin S. Cooper (UEA: University of East Anglia)H-Index: 58
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Background : Unsupervised learning methods such as Hierarchical Cluster Analysis are commonly used for the analysis of genomic platform data. Unfortunately, such approaches ignore the well documented heterogeneous composition of prostate cancer samples. Our aim is to use more sophisticated analytical approaches to deconvolute the structure of prostate cancer transciptome data providing novel clinically actionable information for this disease. Methods : We apply an unsupervised model called Laten...
#1Rohitesh Gupta (UNMC: University of Nebraska Medical Center)H-Index: 1
#2Frank Leon (UNMC: University of Nebraska Medical Center)
Last. Satyendra Kumar (UNMC: University of Nebraska Medical Center)H-Index: 49
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Several reports have shown the role of glycosylation in pancreatic cancer (PC), but a global systematic screening of specific glycosyltransferases (glycoTs) in its progression remains unknown. We demonstrate a rigorous top-down approach using TCGA-based RNA-Seq analysis, multi-step validation using RT-qPCR, immunoblots and immunohistochemistry. We identified six unique glycoTs (B3GNT3, B4GALNT3, FUT3, FUT6, GCNT3 and MGAT3) in PC pathogenesis and studied their function using CRISPR/Cas9-based KD...
#1Annika Bierbrauer (Goethe University Frankfurt)
#2Maureen Jacob (Goethe University Frankfurt)
Last. Simone Fulda (DKFZ: German Cancer Research Center)H-Index: 73
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Despite advances in the treatment of neuroblastoma, patients with high-risk disease still have dismal survival prognosis. Neuroblastoma cells display elevated expression of the antiapoptotic BCL-2 proteins, suggesting that BH3-mimetics may be a promising treatment option. Here, we investigated the role of BCL-2, BCL-XL and MCL-1 in neuroblastoma. A panel of neuroblastoma cell lines and primary patient-derived cells were exposed to BH3-mimetics targeting BCL-2 (ABT-199), BCL-XL (A1331852) or MCL-...
#1Michael S. Toss (Assiut University)H-Index: 4
#2Asima Abidi (University of Nottingham)H-Index: 1
Last. Kylie L. Gorringe (University of Melbourne)H-Index: 27
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The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS. A well characterised DCIS cohort (n = 700) with long-term follow-up comprising pure DCIS (n = 508) and DCIS mixed with invasive carcinoma (IBC; n = 192) were stained immunohistochemically for CD20, CD3, CD4, CD8, FOXP3, PD1 and PDL...
#1Said M. Afify (Menoufia University)H-Index: 1
#2Anna Sanchez CalleH-Index: 4
Last. Juan Du (Okayama University)H-Index: 2
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Liver cancer is the second most common cause of cancer-related death. Every type of tumours including liver cancer contains cancer stem cells (CSCs). To date, the molecular mechanism regulating the development of liver CSCs remains unknown. In this study, we tried to generate a new model of liver CSCs by converting mouse induced pluripotent stem cells (miPSCs) with hepatocellular carcinoma (HCC) cell line Huh7 cells conditioned medium (CM). miPSCs treated with CM were injected into the liver of ...
#1Yoonjin Kwak (Seoul National University Hospital)H-Index: 2
#2Jiwon Koh (Seoul National University Hospital)H-Index: 6
Last. Hye-SeungLee (Seoul National University Bundang Hospital)H-Index: 55
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The aim of the study was to determine the human leucocyte antigen class-I (HLA-I), programmed death-ligand 1 (PD-L1) expression and tumour-infiltrating lymphocytes (TILs) of microsatellite instability-high gastric cancer. The HLA-I expression type was determined by immunohistochemistry of HLA-A, HLA-B, HLA-C and β2-microglobulin in the centre of the tumour (CT) and in the invasive margin (IM) of samples from 293 patients (total loss vs. preserved type). PD-L1 expression and TIL density was exami...
#1Keun Hye Jeon (SKKU: Sungkyunkwan University)
#2Dong Wook Shin (SKKU: Sungkyunkwan University)
Last. Jong ho Cho (SKKU: Sungkyunkwan University)
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Reproductive factors and hormone use in postmenopausal women have been hypothesised to affect the risk of developing lung cancer, but the epidemiological evidence is inconsistent. Using the Korean National Health Insurance System database, we identified 4,775,398 postmenopausal women older than 40 years who had undergone both cardiovascular health- and cancer screening between 1 January 2009 and 31 December 2014. Information about reproductive factors was obtained from a self-administered questi...
#1Anna L. EngelH-Index: 1
#2Nadja I. LorenzH-Index: 3
Last. Anna-Luisa LugerH-Index: 1
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The amino acid serine is an important substrate for biosynthesis and redox homeostasis. We investigated whether glioblastoma (GBM) cells are dependent on serine for survival under conditions of the tumour microenvironment. Serine availability in GBM cells was modulated pharmacologically, genetically and by adjusting serine and glycine concentrations in the culture medium. Cells were investigated for regulation of serine metabolism, proliferation, sensitivity to hypoxia-induced cell death and red...
#1Jun Liu (SNU: Seoul National University)H-Index: 1
#2Junshik Hong (SNU: Seoul National University)H-Index: 17
Last. Sung-Soo Yoon (SNU: Seoul National University)H-Index: 33
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Vitamin C suppresses leukaemogenesis by modulating Tet methylcytosine dioxygenase (TET) activity. However, its beneficial effect in the treatment of patients with acute myeloid leukaemia (AML) remains controversial. In this study, we aimed to identify a potential predictive biomarker for vitamin C treatment in AML. Gene expression patterns and their relevance to the survival of AML patients were analysed with The Cancer Genome Atlas (TCGA) and Therapeutically Applicable Research to Generate Effe...
#1Erfan Taherifard (Shiraz University of Medical Sciences)
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