British Journal of Cancer
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#1Vanessa Tran Chau (Université Paris-Saclay)
#2Winchygn Liu (Université Paris-Saclay)
Last. Céline Clémenson (Université Paris-Saclay)H-Index: 7
view all 8 authors...
Subcutaneous mouse tumour models are widely used for the screening of novel antitumour treatments, although these models are poor surrogate models of human cancers. We compared the antitumour efficacy of the combination of ionising radiation (IR) with two DNA damage response inhibitors, the PARP inhibitor olaparib and the ATR inhibitor AZD6738 (ceralasertib), in subcutaneous versus orthotopic cancer models. Olaparib delayed the growth of irradiated Lewis lung carcinoma (LL2) subcutaneous tumours...
#1Tae Won Kim (SKKU: Sungkyunkwan University)H-Index: 66
#2Yeo Song Lee (SKKU: Sungkyunkwan University)
Last. Yong Beom Cho (SKKU: Sungkyunkwan University)H-Index: 11
view all 7 authors...
Epithelial–mesenchymal transition (EMT) is the most common cause of death in colorectal cancer (CRC). In this study, we investigated the functional roles of miRNA-17-5p in EMT of CRC cells. In order to determine if miRNA-17-5p regulated EMT, the precursors and inhibitors of miR-17-5p were transduced into four CRC cells. To evaluate the regulatory mechanism, we performed argonaute 2 (Ago2) immunoprecipitation (IP) and luciferase assay. In addition, we used an intra-splenic injection mouse model o...
Improving the quality of information and communication is a priority in organised breast cancer screening and an ethical duty. Programmes must offer the information each woman is looking for, promoting informed decision-making. This study aimed to develop and evaluate a web-based dynamic decision aid (DA). A pragmatic randomised trial carried out in six regional organised screening programmes recruited women at the first invitation receiving DA or a web-based standard brochure (SB). The primary ...
#1Ana Babic (Harvard University)H-Index: 12
#2Xuehong Zhang (Brigham and Women's Hospital)H-Index: 28
Last. Brian M. Wolpin (Harvard University)H-Index: 48
view all 15 authors...
Despite several plausible biological mechanisms linking proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RAs) with colorectal tumorigenesis, their association with risk of colorectal cancer (CRC) has not been adequately assessed in prospective epidemiological studies. We evaluated the association of acid-suppressive medication use with CRC risk among 175,871 (PPI) and 208,831 (H2RA) participants from three large prospective cohort studies. Medication use was assessed at baseline and ...
#1Fergus Macbeth (Cardiff University)H-Index: 15
#2Lj Fallowfiled (University of Sussex)H-Index: 80
Pulmonary metastasectomy is widely and increasingly practiced in the belief that this intervention can cure patients with colorectal cancer, and that without it few survive 5 years. No good evidence exists supporting such convictions, indeed recent trial results challenge them. What evidence underpins this acceptance of illusory truths or misconceptions?
#1Joseph Ciccolini (AMU: Aix-Marseille University)H-Index: 29
#2Sébastien BenzekryH-Index: 14
Last. Fabrice Barlesi (AMU: Aix-Marseille University)H-Index: 48
view all 3 authors...
This project aims to generate dense longitudinal data in lung cancer patients undergoing anti-PD1/PDL1 therapy. Mathematical modelling with mechanistic learning algorithms will help decipher the mechanisms underlying the response or resistance to immunotherapy. A better understanding of these mechanisms should help identifying actionable items to increase the efficacy of immune-checkpoint inhibitors.
#1Oliver J Pickles (University of Birmingham)H-Index: 2
#2Lennard Y. W. Lee (University of Birmingham)H-Index: 2
Last. Gary Middleton (University of Birmingham)H-Index: 39
view all 10 authors...
The rapid emergence of COVID-19 has sent shockwaves through healthcare systems globally, with cancer patients at increased risk. The interplay of the virus and host immune system has been implicated in the development of ARDS. Immunotherapy agents have the potential to adversely potentiate this phenomenon, requiring careful real-world observation.
#1Hasan Baysal (University of Antwerp)H-Index: 1
#2Ines De Pauw (University of Antwerp)H-Index: 2
Last. Julie Jacobs (University of Antwerp)H-Index: 7
view all 11 authors...
The epidermal growth factor receptor (EGFR) is overexpressed by 80–90% of squamous cell carcinoma of head and neck (HNSCC). In addition to inhibiting EGFR signal transduction, cetuximab, a monoclonal antibody targeting EGFR can also bind to fragment crystallisable domain of immunoglobulins G1 present on natural killer (NK), causing antibody-dependent cellular cytotoxicity (ADCC). However, presence of cetuximab resistance limits effective clinical management of HNSCC. In this study, differences i...
#1Abdulmohsen M Alruwetei (UNSW: University of New South Wales)
#2Katerina Bendak (UNSW: University of New South Wales)H-Index: 5
Last. Richard B. Lock (UNSW: University of New South Wales)H-Index: 47
view all 9 authors...
While current chemotherapy has increased cure rates for children with acute lymphoblastic leukaemia (ALL), the largest number of relapsing patients are still stratified as medium risk (MR) at diagnosis (50–60%). This highlights an opportunity to develop improved relapse-prediction models for MR patients. We hypothesised that bone marrow from MR patients who eventually relapsed would regrow faster in a patient-derived xenograft (PDX) model after induction chemotherapy than samples from patients i...
#1Wei-Hsin Yuan (NYMU: National Yang-Ming University)H-Index: 4
#2Hui-Chen HsuH-Index: 3
Last. Chia-Hung Wu (NYMU: National Yang-Ming University)
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Mammography is not effective in detecting breast cancer in dense breasts. A search in Medline, Cochrane, EMBASE and Google Scholar databases was conducted from January 1, 1980 to April 10, 2019 to identify women with dense breasts screened by mammography (M) and/or ultrasound (US). Meta-analysis was performed using the random-effect model. A total of 21 studies were included. The pooled sensitivity values of M alone and M + US in patients were 74% and 96%, while specificity of the two methods we...
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