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British Journal of Cancer
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5.42
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Papers 24602
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#1Anton Pottegård (University of Southern Denmark)H-Index: 22
#2Sidsel Arnspang Pedersen (University of Southern Denmark)H-Index: 2
Last.Edward Chia-Cheng Lai (NCKU: National Cheng Kung University)H-Index: 12
view all 8 authors...
The antihypertensive agent hydrochlorothiazide has been associated with increased risks of non-melanoma skin cancer (NMSC) and possibly some melanoma subtypes. Previous studies were, however, conducted in predominantly Caucasian populations. We therefore examined the association between hydrochlorothiazide and skin cancer risk in an Asian population. By using Taiwan’s National Health Insurance Research Database (NHIRD), we conducted three separate case–control studies of lip cancer, non-lip non-...
#1Amanda R. Noble (Ebor: University of York)H-Index: 3
#2Karen G. Hogg (Ebor: University of York)H-Index: 8
Last.Martin G. Rumsby (Ebor: University of York)H-Index: 23
view all 7 authors...
Phospholipases D1 and D2 (PLD1/2) are implicated in tumorigenesis through their generation of the signalling lipid phosphatidic acid and its downstream effects. Inhibition of PLD1 blocks prostate cell growth and colony formation. Here a role for PLD2 in prostate cancer (PCa), the major cancer of men in the western world, is examined. PLD2 expression was analysed by immunohistochemistry and western blotting. The effects of PLD2 inhibition on PCa cell viability and cell motility were measured usin...
#1Sandeep Kumar (UIC: University of Illinois at Chicago)H-Index: 3
#2Jordan O’MalleyH-Index: 5
Last.Dhyan ChandraH-Index: 18
view all 7 authors...
Interleukin-8 (IL-8) and heat shock protein 60 (Hsp60) play crucial roles in cell survival and maintenance of cellular homoeostasis. However, cross talks between these two proteins are not defined. IL-8 expression in tumour tissue sections was analysed by immunohistochemistry. IL-8 expression and release in cancer cells was quantified using enzyme-linked immunosorbent assay (ELISA). Apoptosis was quantified using caspase activity and Annexin-V/PI staining. We observed IL-8 release from cancer ce...
#1Monica Tang (UNSW: University of New South Wales)H-Index: 1
#2Andrea L. Schaffer (UNSW: University of New South Wales)H-Index: 7
Last.Sallie-Anne Pearson (UNSW: University of New South Wales)H-Index: 28
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Randomised clinical trials (RCTs) demonstrate that trastuzumab improves survival in patients with human epidermal growth factor 2-positive early breast cancer (HER2 + EBC), but real-world patients and clinical practice often differ from RCTs. We examine real-world treatment patterns and outcomes associated with trastuzumab for HER2 + EBC. We identified all Australians dispensed trastuzumab for HER2 + EBC between 1/1/2007 and 30/6/2016. We estimated the proportion of patients completing 12 months...
#1Yuki Kita (Kyoto University)H-Index: 3
#2Akihiro Hamada (Kyoto University)
Last.Takashi Kobayashi (Kyoto University)H-Index: 21
view all 16 authors...
Since the standard gemcitabine and cisplatin (GC) chemotherapy for advanced bladder cancer yields limited therapeutic effect due to chemoresistance, it is a clinical challenge to enhance sensitivity to GC. We performed high-throughput screening by using a library of known chemicals and repositionable drugs. A total of 2098 compounds were administered alone or with GC to human bladder cancer cells, and chemicals that enhanced GC effects were screened. Disulfiram (DSF), an anti-alcoholism drug, wa...
Selection of cancer patients for treatment with immune checkpoint inhibitors remains a challenge due to tumour heterogeneity and variable biomarker detection. PD-L1 expression in 24 surgical chordoma specimen was determined immunohistochemically with antibodies 28-8 and E1L3N. The ability of patient-derived organoids to detect treatment effects of nivolumab was explored by quantitative and qualitative immunofluorescence and FACS analysis. The more sensitive antibody, E1L3N (ROC = 0.896, p = 0.00...
#1Juliana Müller Bark (QUT: Queensland University of Technology)
#2Arutha Kulasinghe (QUT: Queensland University of Technology)H-Index: 10
Last.Chamindie Punyadeera (QUT: Queensland University of Technology)H-Index: 24
view all 5 authors...
Gliomas are the most common tumours of the central nervous system and the most aggressive form is glioblastoma (GBM). Despite advances in treatment, patient survival remains low. GBM diagnosis typically relies on imaging techniques and postoperative pathological diagnosis; however, both procedures have their inherent limitations. Imaging modalities cannot differentiate tumour progression from treatment-related changes that mimic progression, known as pseudoprogression, which might lead to misint...
Maturation of complex N-glycans involves the action of Golgi mannosidases and plays a major role in cancer progression. We recently showed a favourable prognostic role of α-mannosidase MAN1A1 in breast cancer mainly caused by alteration of certain adhesion molecules. We analysed the protein expression of MAN1A1 in ovarian cancer (n = 204) using western blot and studied the impact of MAN1A1 itself and of MAN1A1-related glycosylation on the prognostic relevance of two adhesion molecules. Functiona...
#1Thomas H. Beckham (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
#2Jonathan E. Leeman (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 11
Last.C. Jillian Tsai (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 6
view all 11 authors...
Our objective was to evaluate the outcomes of metastatic head and neck squamous cell carcinoma (HNSCC) by disease burden with an emphasis on metastasis-directed therapy (MDT) in patients with limited metastatic disease burden. In total, 186 patients who developed metastatic disease after definitive therapy for HNSCC were included. Clinically and radiographically apparent metastases were enumerated. Kaplan–Meier methods were used to estimate survival. Cox regression was used to assess the associa...
#1Tracey Genus (PHE: Public Health England)
Last.John Ramage (University of Cambridge)H-Index: 35
view all 16 authors...
The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates (SMRs) were calculated for all malignant NENs diagnosed 2013–2015 from UK national Public Health records. Comparison with non-NENs assessed 1-year overall survival (1YS) and association between diagn...
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