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British Journal of Cancer
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5.42
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Papers 24726
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#1Diana FarhatH-Index: 1
#2Sophie LéonH-Index: 2
Last.Hubert LincetH-Index: 11
view all 8 authors...
Breast cancer is the second most common cancer in the world. Despite advances in therapies, the mechanisms of resistance remain the underlying cause of morbidity and mortality. Lipoic acid (LA) is an antioxidant and essential cofactor in oxidative metabolism. Its potential therapeutic effects have been well documented, but its mechanisms of action (MOA) are not fully understood. The aim of this study is to validate the inhibitory LA effect on the proliferation of various breast cancer cell lines...
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#1Shi-wei Guo ('SMMU': Second Military Medical University)H-Index: 1
#2Xiaohan Shi ('SMMU': Second Military Medical University)H-Index: 1
Last.Zhuo Shao ('SMMU': Second Military Medical University)H-Index: 5
view all 11 authors...
About 25–37% of resectable pancreatic ductal adenocarcinoma (PDAC) had a great chance of early recurrence after radical resection, which is mainly due to preoperative micrometastasis. We herein demonstrated the profiles of ctDNA in resectable PDAC and use of ctDNA to identify patients with potential micrometastasis. A total of 113 and 44 resectable PDACs were enrolled in discovery and validation cohorts, separately. A panel containing 50 genes was used to screen ctDNA by an NGS-based assessment ...
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Immune checkpoint blockade (ICB) therapy improved the prognosis of cancer patients, but general administration of ICBs occasionally induces side effects that include immune-related adverse events and tumour hyper-progression. Here, we established a protein-based system, by which endogenous expression of IC molecule in natural killer (NK) cells was transiently repressed on enhancement of their antitumour activity. A protein-based genome modulator (GM) system is composed of a transcription activat...
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#1Jessica C. Casciano (Wistar Institute)
#2Caroline E. Perry (UPenn: University of Pennsylvania)
Last.Zachary T. Schug (Wistar Institute)H-Index: 12
view all 23 authors...
Background: Recent studies have suggested that fatty acid oxidation (FAO) is a key metabolic pathway for the growth of triple negative breast cancers (TNBC), particularly those that have high expression of MYC. However, the underlying mechanism by which MYC promotes FAO remains poorly understood. Methods: We used a combination of metabolomics, transcriptomics, bioinformatics and microscopy to elucidate a potential mechanism by which MYC regulates FAO in TNBC. Results: We propose that MYC induces...
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#1Benjamin B. Mull (University of Texas MD Anderson Cancer Center)H-Index: 1
#2J. Andrew Livingston (University of Texas MD Anderson Cancer Center)H-Index: 4
Last.Khandan Keyomarsi (University of Texas MD Anderson Cancer Center)H-Index: 9
view all 6 authors...
Low-dose UCN-01 mediates G1 arrest in normal proliferating cell lines with an intact G1 to S transition but not tumour cells with a deregulated G1 to S checkpoint. Here we hypothesised that UCN-01 is effective in mediating a selective, reversible G1 arrest of normal proliferating cells, resulting in decreased chemotoxicity, improved tolerance and enhanced chemotherapeutic efficacy in vivo in both non-tumour-bearing mice and in breast cancer cell line xenograft models. Murine small bowel epitheli...
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#1Moritz Jesinghaus (TUM: Technische Universität München)H-Index: 11
#2Katja Steiger (TUM: Technische Universität München)H-Index: 18
Last.Melanie Boxberg (TUM: Technische Universität München)H-Index: 6
view all 19 authors...
Pre-operative treatment planning in head and neck squamous cell carcinoma (HNSCC) is mainly dictated by clinical staging, which has major shortcomings. Histologic grading is irrelevant due to its lack of prognostic impact. Recently, a novel grading termed Cellular Dissociation Grade (CDG) based on Tumour Budding and Cell Nest Size was shown to be highly prognostic for resected HNSCC. We aimed to probe the predictive and prognostic impact of CDG in the pre-operative biopsies of HNSCC. We evaluate...
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#1Mounia Beloueche-Babari (The Royal Marsden NHS Foundation Trust)H-Index: 12
#2Teresa Casals Galobart (The Royal Marsden NHS Foundation Trust)H-Index: 2
Last.Martin O. Leach (The Royal Marsden NHS Foundation Trust)H-Index: 70
view all 8 authors...
Monocarboxylate transporter 1 (MCT1) is a regulator of cell metabolism and a therapeutic target for cancer treatment. Understanding the changes in tumour function accompanying MCT1 inhibition will better characterise the anti-tumour effects of MCT1 inhibitors, potentially enabling the identification of pharmacodynamic biomarkers for the clinical development of these agents. We assessed the impact of the MCT1 inhibitor AZD3965 on tumour metabolism and immune cell infiltration as key determinants ...
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#1Harry J. Whitwell (UCL: University College London)H-Index: 6
#2Jenny Worthington (UCL: University College London)H-Index: 4
Last.John F. Timms (UCL: University College London)H-Index: 30
view all 11 authors...
Ovarian cancer has a poor survival rate due to late diagnosis and improved methods are needed for its early detection. Our primary objective was to identify and incorporate additional biomarkers into longitudinal models to improve on the performance of CA125 as a first-line screening test for ovarian cancer. This case–control study nested within UKCTOCS used 490 serial serum samples from 49 women later diagnosed with ovarian cancer and 31 control women who were cancer-free. Proteomics-based biom...
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#1Afroditi Nanou (UT: University of Twente)H-Index: 3
#2M. Craig MillerH-Index: 35
Last.Leon W. M. M. Terstappen (UT: University of Twente)H-Index: 50
view all 9 authors...
Circulating tumour cells (CTCs) in blood associate with overall survival (OS) of cancer patients, but they are detected in extremely low numbers. Large tumour-derived extracellular vesicles (tdEVs) in castration-resistant prostate cancer (CRPC) patients are present at around 20 times higher frequencies than CTCs and have equivalent prognostic power. In this study, we explored the presence of tdEVs in other cancers and their association with OS. The open-source ACCEPT software was used to automat...
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#1Xiao-Hang Wang (PKU: Peking University)
#2Liu-Hua Long (PKU: Peking University)
Last.Weihu Wang (PKU: Peking University)H-Index: 2
view all 10 authors...
Recurrence is the major cause of mortality in patients with resected HCC. However, without a standard approach to evaluate prognosis, it is difficult to select candidates for additional therapy. A total of 201 patients with HCC who were followed up for at least 5 years after curative hepatectomy were enrolled in this retrospective, multicentre study. A total of 3144 radiomics features were extracted from preoperative MRI. The random forest method was used for radiomics signature building, and fi...
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