Original paper
An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma
Volume: 116, Issue: 46, Pages: 23264 - 23273
Published: Oct 29, 2019
Abstract
Glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) plays a critical role in cancer metabolism by coordinating glycolysis and biosynthesis. A well-validated PGAM1 inhibitor, however, has not been reported for treating pancreatic ductal adenocarcinoma (PDAC), which is one of the deadliest malignancies worldwide. By uncovering the elevated PGAM1 expressions were statistically related to worse prognosis of PDAC in a cohort of 50 patients, we...
Paper Details
Title
An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma
Published Date
Oct 29, 2019
Volume
116
Issue
46
Pages
23264 - 23273
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Notes
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