TAF1 plays a critical role in AML1-ETO driven leukemogenesis
Abstract
AML1-ETO (AE) is a fusion transcription factor, generated by the t(8;21) translocation, that functions as a leukemia promoting oncogene. Here, we demonstrate that TATA-Box Binding Protein Associated Factor 1 (TAF1) associates with K43 acetylated AE and this association plays a pivotal role in the proliferation of AE-expressing acute myeloid leukemia (AML) cells. ChIP-sequencing indicates significant overlap of the TAF1 and AE binding sites....
Paper Details
Title
TAF1 plays a critical role in AML1-ETO driven leukemogenesis
Published Date
Oct 29, 2019
Journal
Volume
10
Issue
1
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