IL‐35, a double‐edged sword in cancer

Interleukin 35 (IL‐35), a cytokine mainly produced by regulatory T cells (Treg cells), is composed of an Epstein‐Barr virus–induced gene 3 β‐chain and an IL‐12 p35 α‐chain. IL‐35 causes tumorigenicity in cancer, protects cancer cells against apoptosis, and facilitates cancer progression. However, a few reports have referred to its contradictory roles in cancer prevention. Therefore, the exact purpose of this cytokine in cancer development has...