Thyroid Hormone Status Regulates Skeletal Muscle Response to Chronic Motor Nerve Stimulation

Although both exercise and thyroid hormone (TH) status can cause cellular and metabolic changes in skeletal muscle, the impact of TH status on exercise-associated changes is not well understood. Here, we examined the effects of TH status on muscle fiber type, cell signaling, and metabolism in a rabbit model of exercise training — chronic motor nerve stimulation (CMNS). Five rabbits were rendered hypothyroid for seven to eight weeks and three...