doi.org/10.1038/s41419-019-2034-y

Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer

..., Naoki Itano
37
Cell Death and Disease8.10
Volume: 10, Issue: 11
Published: Oct 23, 2019
Abstract
The hexosamine biosynthetic pathway (HBP) metabolically regulates dynamic cellular events by linking nutrient availability to numerous signaling networks. Significant alterations in the HBP are often associated with cancer pathogenesis. In this study, we investigated the molecular events underlying cancer pathogenesis associated with enhanced HBP flux. Multidimensional analysis of microarray datasets demonstrated up-regulation of genes encoding...
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Paper Details
Title
Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer
DOI
doi.org/10.1038/s41419-019-2034-y
Published Date
Oct 23, 2019
Journal
Cell Death and Disease
Volume
10
Issue
11
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