Bacterial biodiversity drives the evolution of CRISPR-based phage resistance
Abstract
About half of all bacteria carry genes for CRISPR-Cas adaptive immune systems1, which provide immunological memory by inserting short DNA sequences from phage and other parasitic DNA elements into CRISPR loci on the host genome2. Whereas CRISPR loci evolve rapidly in natural environments3,4, bacterial species typically evolve phage resistance by the mutation or loss of phage receptors under laboratory conditions5,6. Here we report how this...
Paper Details
Title
Bacterial biodiversity drives the evolution of CRISPR-based phage resistance
Published Date
Oct 23, 2019
Journal
Volume
574
Issue
7779
Pages
549 - 552
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