Original paper
Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells
Abstract
Over half of cutaneous melanoma tumors have BRAFV600E/K mutations. Acquired resistance to BRAF inhibitors (BRAFi) remains a major hurdle in attaining durable therapeutic responses. In this study we demonstrate that ~50-60% of melanoma cell lines with vemurafenib resistance acquired in vitro show activation of RhoA family GTPases. In BRAFi-resistant melanoma cell lines and tumors, activation of RhoA is correlated with decreased expression of...
Paper Details
Title
Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells
Published Date
Oct 28, 2019
Journal
Volume
39
Issue
7
Pages
1466 - 1483
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History