Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?

There is ongoing concern regarding increased toxicity from paclitaxel in elderly patients, particularly of severe neutropenia. Yet, data so far is controversial and this concern is not supported by a clinically relevant age-dependent difference in pharmacokinetics (PK) of paclitaxel. This study assessed whether age is associated with increased risk for paclitaxel-induced neutropenia.Paclitaxel plasma concentration-time data, pooled from multiple...