Original paper
pH-triggered endosomal escape of pore-forming Listeriolysin O toxin-coated gold nanoparticles
Abstract
Background A major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest. In nature, the bacterial pathogen Listeria monocytogenes has developed a strategy to secrete Listeriolysin O (LLO) toxin as a tool to escape the eukaryotic lysosomal system upon infection, allowing it to grow and proliferate...
Paper Details
Title
pH-triggered endosomal escape of pore-forming Listeriolysin O toxin-coated gold nanoparticles
Published Date
Oct 17, 2019
Journal
Volume
17
Issue
1
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Notes
History