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Journal of Nanobiotechnology
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5.34
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803
Papers 803
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Background The increasing use of gold nanoparticles (AuNPs) in the field of neuroscience instilled hope for their rapid translation to the clinical practice. AuNPs can be engineered to carry therapeutics or diagnostics in the diseased brain, possibly providing greater cell specificity and low toxicity. Although there is a general enthusiasm for these tools, we are in early stages of their development. Overall, their brain penetrance, stability and cell specificity are critical issues that must b...
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#1Shipra Malik (UConn: University of Connecticut)H-Index: 2
#2Raman Bahal (UConn: University of Connecticut)H-Index: 12
Numerous first generation phosphorothioates (PS) and their derivatives have shown promise targeting mRNA for therapeutic applications and also gained market approval for their use as a drug. However, PS have not been explored for targeting microRNAs (miRNAs or miRs). In particular, efficient delivery remains a critical cog in PS-based antimiR applications. In this study, we tested and characterized a series of poly-lactic-co-glycolic-acid (PLGA) polymers of different molecular weights that can e...
1 CitationsSource
#1Jiayu Zhang (JLU: Jilin University)H-Index: 1
#2Tiancheng Zhao (JLU: Jilin University)H-Index: 1
Last.Yezhou Li (JLU: Jilin University)H-Index: 1
view all 5 authors...
The gastric cancer is the second most malignant tumor in the world. HER-2 is one of the key targets for the gastric cancer therapy. Anti-HER-2 antibodies like trastuzumab, exhibits the satisfactory therapeutic effect in clinical. However, the drug resistance problem limits its application. In this study, we develop a gold nanoshell (Gold Nanoshell) drug carrier for delivery and selective photo-thermal release of genes which target HER-2 and immunologic adjuvant CPG sequence in gastric tumor cell...
1 CitationsSource
#1Zunfu Hu (LYU: Linyi University)H-Index: 3
#2Zhichao Dai (LYU: Linyi University)H-Index: 3
Last.Yueqin Yu (QUST: Qingdao University of Science and Technology)
view all 8 authors...
Rapid and sensitive detection of H2O2 especially endogenous H2O2 is of great importance for series of industries including disease diagnosis and therapy. In this work, uniform FePt nanoparticles are successfully anchored onto Few-layer molybdenum disulfide nanosheets (F-MoS2 NSs). The powder X-ray diffraction, transmission electron microscopy, UV–Vis spectra and atomic force microscopy were employed to confirm the structure of the obtained nanocomposites (F-MoS2-FePt NCs). The prepared nanocompo...
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#1Joanna Depciuch (PAN: Polish Academy of Sciences)H-Index: 10
#2Małgorzata Stec (Jagiellonian University Medical College)H-Index: 3
Last.Magdalena Parlinska-Wojtan (PAN: Polish Academy of Sciences)H-Index: 8
view all 5 authors...
New nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosensitizers in PTT. Light microscopy images of two colon cancer cell lines (SW480, SW620) showed, that the laser irradiation combined with PtAu NRs caused visible changes in the cell morphology. Fourier Transform InfraRed (FTIR) and Raman spectroscopies showed chemical changes in the DNA, phos...
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#1Hind Baballa Gasmalla (YZU: Yangzhou University)H-Index: 1
#2Xiaoquan Lu (Northwest Normal University)H-Index: 28
Last.Guowang Diao (YZU: Yangzhou University)
view all 6 authors...
Background Iron oxide nanocomposites have received a great attention for their application in various fields like physics, medicine, biology, and material science etc., due to their unique properties, such as magnetism, electrical properties, small size, biocompatibility and low toxicity.
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#1Robert Bucki (UMB: Medical University of Białystok)H-Index: 30
#2Katarzyna Niemirowicz-Laskowska (UMB: Medical University of Białystok)H-Index: 2
Last.Paul A. Janmey (UPenn: University of Pennsylvania)H-Index: 89
view all 10 authors...
Magnetic nanoparticles (MNPs) are characterized by unique physicochemical and biological properties that allow their employment as highly biocompatible drug carriers. Gelsolin (GSN) is a multifunctional actin-binding protein involved in cytoskeleton remodeling and free circulating actin sequestering. It was reported that a gelsolin derived phosphoinositide binding domain GSN 160–169, (PBP10 peptide) coupled with rhodamine B, exerts strong bactericidal activity. In this study, we synthesized a ne...
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#1Ismael Plaza-GA (Complutense University of Madrid)
#2Vanesa Manzaneda-González (Complutense University of Madrid)
Last.Iván López Montero (Complutense University of Madrid)
view all 9 authors...
A major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest. In nature, the bacterial pathogen Listeria monocytogenes has developed a strategy to secrete Listeriolysin O (LLO) toxin as a tool to escape the eukaryotic lysosomal system upon infection, allowing it to grow and proliferate unharmed inside the host cell. As a “proof of concept”, we present he...
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#1Laura Sanz-Ortega (CSIC: Spanish National Research Council)H-Index: 4
#2José M. Rojas (CSIC: Spanish National Research Council)H-Index: 13
Last.Domingo F. Barber (CSIC: Spanish National Research Council)H-Index: 28
view all 6 authors...
Background T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportion of administered cells that reaches the region of interest. Manipulating T cell localisation to improve specific targeting will increase the effectiveness of these therapies. Nanotechnology has been successfully used for localized release of drugs and biomol...
4 CitationsSource
#1Chia-Cheng Yu (MCUT: Ming Chi University of Technology)H-Index: 1
#2Yi-Wen Chen (AS: Academia Sinica)H-Index: 1
Last.Peilin Chen (AS: Academia Sinica)H-Index: 27
view all 11 authors...
Circulating tumor cells (CTCs) comprise the high metastatic potential population of cancer cells in the blood circulation of humans; they have become the established biomarkers for cancer diagnosis, individualized cancer therapy, and cancer development. Technologies for the isolation and recovery of CTCs can be powerful cancer diagnostic tools for liquid biopsies, allowing the identification of malignancies and guiding cancer treatments for precision medicine. We have used an electrospinning pro...
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