Original paper
Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis
Abstract
The mechanistic target of rapamycin complex 2 (mTORC2) is a potentially novel and promising anticancer target due to its critical roles in proliferation, apoptosis, and metabolic reprogramming of cancer cells. However, the activity and function of mTORC2 in distinct cells within malignant tissue in vivo is insufficiently explored. Surprisingly, in primary human and mouse colorectal cancer (CRC) samples, mTORC2 signaling could not be detected in...
Paper Details
Title
Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis
Published Date
Oct 17, 2019
Journal
Volume
4
Issue
20
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Notes
History