Management of toxicity to isoform α-specific PI3K inhibitors
Abstract
Alterations in the phosphoinositide 3-kinase (PI3K)/AKT pathway are frequently found in cancer and are especially common in breast cancer, where it is estimated that 70% of tumors have some type of genetic alteration that could lead to pathway hyperactivation. A variety of PI3K pathway inhibitors have been developed in an attempt to target this pathway and improve cancer control. One of the challenges in treating patients with PI3K/AKT pathway...
Paper Details
Title
Management of toxicity to isoform α-specific PI3K inhibitors
Published Date
Dec 1, 2019
Journal
Volume
30
Pages
x21 - x26
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Notes
History