Ghrelin Signaling: GOAT and GHS-R1a Take a LEAP in Complexity
Volume: 31, Issue: 2, Pages: 107 - 117
Published: Feb 1, 2020
Abstract
Ghrelin octanoylation by ghrelin O-acyltransferase represents a key control point in metabolic signaling. Recent advances in GOAT inhibitor development offer the potential to target ghrelin signaling through GOAT for therapeutic effect. The discovery of LEAP2, an endogenous GHS-R1a antagonist secreted by the liver. Identification of proteins that interact with GHS-R1a to modulate receptor activation expands the landscape of ghrelin–GHS-R1a...
Paper Details
Title
Ghrelin Signaling: GOAT and GHS-R1a Take a LEAP in Complexity
Published Date
Feb 1, 2020
Volume
31
Issue
2
Pages
107 - 117
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