Abstract 873: Acetate Protects the Heart Against Ischemic Injury by Alternating TCA Cycle-related Metabolites and AMP-activated Protein Kinase

Introduction: Acetate is preferentially taken up in the heart, and converted into acetyl-CoA by acetyl-CoA synthetase2 (AceCS2), which is abundant in the mitochondria of cardiomyocytes, resulting in activation of AMPK through an elevation of AMP/ATP ratio. In this context, we investigated the effects of acetate on myocardial ischemic injury in isolated cardiomyocytes and in vivo mouse hearts. Methods and Results: In isolated cardiomyocytes, 13...