Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications

• Monoacylglycerol lipase is responsible for hydrolysis of a major endocannabinoid. • Monoacylglycerol lipase can be harnessed to control endogenous signaling lipids. • Imaging brain enzymes can be used to quantify their expression and activity in vivo . Endocannabinoid degrading enzymes regulate the concentrations of a variety of biomolecules, many of which are consequential in clinical pathologies. Monoacylglycerol lipase (MAGL) is the major...