Abstract 640: Indigo Naturalis, a Promising Herbal Medicine for Ulcerative Colitis, Can Induce Experimental Pulmonary Arterial Hypertension via Aryl Hydrocarbon Pathway

Background: Indigo naturalis is a Chinese herbal medicine, whose dramatical effects for treatment of ulcerative colitis have been reported. However, some patients who took indigo naturalis developed pulmonary arterial hypertension (PAH), which is a poor prognostic disease with right ventricular (RV) failure and progressive remodeling of pulmonary vessels. Aims: We examined the reproducibility in experimental animals and elucidate the mechanisms...