Clinical Cirrhosis Dilemmas: Survey of Practice from the 7th International Coagulation in Liver Disease Conference

Published on Oct 18, 2019in Digestive Diseases and Sciences2.937
· DOI :10.1007/s10620-019-05884-0
Jonathan G. Stine2
Estimated H-index: 2
(PSU: Pennsylvania State University),
Jonathan G. Stine13
Estimated H-index: 13
(PSU: Pennsylvania State University)
+ 4 AuthorsCurtis K. Argo27
Estimated H-index: 27
(UVA: University of Virginia)
Introduction and Aim Hemostatic disorders in chronic liver disease and cirrhosis show continued expansion of research efforts. However, clinical decision making is often practiced on an individual patient level as consensus guidelines are lacking. We aimed to better assess individual day-to-day clinical practice through gauging clinicians’ responses to common clinical scenarios.
  • References (23)
  • Citations (0)
📖 Papers frequently viewed together
3 Citations
8 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Nicolas M. Intagliata (UVA: University of Virginia)H-Index: 11
#2Curtis K. Argo (UVA: University of Virginia)H-Index: 27
Last. Francesco Violi (Sapienza University of Rome)H-Index: 62
view all 6 authors...
16 CitationsSource
2 CitationsSource
#1Jonathan G. Stine (UVA: University of Virginia)H-Index: 13
#2Patrick G. Northup (UVA: University of Virginia)H-Index: 32
8 CitationsSource
#1G. NapolitanoH-Index: 14
#2A. IacobellisH-Index: 14
Last. Angelo AndriulliH-Index: 61
view all 11 authors...
Abstract Background In cirrhotics with low circulating platelets (PLT), restoration of normal cell counts has been traditionally recommended before invasive procedures. However, there is neither consensus on the PLT transfusion threshold nor evidence of its clinical efficacy. Patients In order to fill this gap of knowledge, we prospectively collected and analyzed data on circulating PLT counts [and International Normalized Ratio (INR)] values in a case series of 363 cirrhotics scheduled to under...
27 CitationsSource
#1Nadia Cocero (UNITO: University of Turin)H-Index: 5
#2Marta Bezzi (UNITO: University of Turin)H-Index: 1
Last. Stefano Carossa (UNITO: University of Turin)H-Index: 18
view all 4 authors...
Purpose Cirrhotic patients awaiting liver transplantation require eradication of infectious oral foci to prevent septic episodes after transplantation; however, cirrhosis can hinder hemostasis and can result in severe bleeding. The present study assessed the bleeding risk factors connected with the clinical history of these patients and the characteristics of the extractions. Materials and Methods We retrospectively analyzed 1183 extractions in 318 patients, including 47 with severe end-stage li...
8 CitationsSource
#1Kumar Shiva Gubbiyappa (International Medical University)H-Index: 2
#2Ankur Barua (International Medical University)H-Index: 10
Last. Hasnain Zafar Baloch (International Medical University)H-Index: 1
view all 5 authors...
Objectives: Flipped classroom (FC) is a pedagogical model to engage students in learning process by replacing the didactic lectures. Using technology, lectures are moved out of the classroom and delivered online as means to provide interaction and collaboration. Poll Everywhere is an audience response system (ARS) which can be used in an FC to make the activities more interesting, engaging, and interactive. This study aims to study the perception of undergraduate pharmacy students on FC activity...
6 CitationsSource
#1Andreas DrolzH-Index: 9
#2Thomas HorvatitsH-Index: 12
Last. Valentin FuhrmannH-Index: 26
view all 14 authors...
Disturbances of coagulation and hemostasis are common in patients with liver cirrhosis. The typical laboratory pattern mimics disseminated intravascular coagulation (DIC). The aim of this study was to assess the impact of routine coagulation parameters in critically ill cirrhosis patients with regard to new onset of major bleeding and outcome. A total of 1,493 critically ill patients were studied prospectively. Routine coagulation parameters were assessed, and the DIC score was calculated based ...
52 CitationsSource
#1Paola Frati (American Board of Legal Medicine)H-Index: 15
#2Francesco Paolo Busardò (Sapienza University of Rome)H-Index: 18
Last. Vittorio Fineschi (Sapienza University of Rome)H-Index: 27
view all 6 authors...
Although in literature few successful claims have been shown in comparison with other medical specialties such as gynaecology and orthopaedics, vascular surgery is included among high-risk specialties. The high-risk of receiving medical claims may lead vascular surgeons to practice defensive medicine, as is normal in several other areas of clinical practice. No studies are available to our knowledge of the incidence of defensive medicine in the field of vascular surgery. Taking into consideratio...
5 CitationsSource
#1Freeha Arshad (UMCG: University Medical Center Groningen)H-Index: 6
#2Ton Lisman (UMCG: University Medical Center Groningen)H-Index: 51
Last. Robert J. Porte (UMCG: University Medical Center Groningen)H-Index: 58
view all 3 authors...
Traditionally, perioperative bleeding complications were a major concern during orthotopic liver transplantation, but a tremendous decline in transfusion requirements has been reported over the last decade. In recent years, there has been an increasing awareness towards perioperative thrombotic complications, including liver vessel thrombosis, and systemic venous and arterial thromboembolic events. Whereas a number of these thrombotic complications were previously categorized as surgical complic...
35 CitationsSource
#1Xingshun Qi (Fourth Military Medical University)H-Index: 1
#2Hui Chen (Fourth Military Medical University)H-Index: 11
Last. Guohong Han (Fourth Military Medical University)H-Index: 1
view all 3 authors...
Abstract Background The effects of antithrombin (AT), protein C (PC) and protein S (PS) on the pathogenesis of portal vein thrombosis (PVT) in liver cirrhosis remain controversial in different studies. In this study, a systematic review and meta-analysis to examine this issue were performed. Methods PubMed database was employed to identify all studies in which AT, PC and PS concentrations were measured in both cirrhotic patients with and without PVT. A standardized mean difference (SMD) with 95%...
23 CitationsSource
Cited By0