Human signal transducer and activator of transcription 5b (STAT5b) mutation causes dysregulated human natural killer cell maturation and impaired lytic function

BackgroundPatients with signal transducer and activator of transcription 5b (STAT5b) deficiency have impairment in T-cell homeostasis and natural killer (NK) cells which leads to autoimmunity, recurrent infections, and combined immune deficiency.ObjectiveIn this study we characterized the NK cell defect in STAT5b-deficient human NK cells, as well as Stat5b−/− mice.MethodsWe used multiparametric flow cytometry, functional NK cell assays,...