The role of α7nAChR in controlling the anti-inflammatory/anti-arthritic action of galantamine

The evolution of the “cholinergic anti-inflammatory pathway” and the fact that the α 7 subunit of the nicotinic acetylcholine receptor (α7nAChR) is present in the spleen, joint and on the surface of lymphocytes, opened up the prospective in this study of targeting the α7nAChR by the anticholinesterase and cholinergic drug, galantamine, to control inflammation in rheumatoid arthritis (RA). Twelve-adjuvant arthritic rats were exposed to the...